机构：[a]Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China临床科室神经内科首都医科大学附属安贞医院[b]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经病学中心首都医科大学附属天坛医院
It is important to identify candidates who warrant extended cardiac monitoring after ischemic stroke. We investigated the predictive performance of the CHADS(2) and CHA(2)DS(2)-VASc scores for previously unknown atrial fibrillation during in-hospital electrocardiographic monitoring. Patients were selected from a prospective trial in China. The clinical prediction of the scores was examined using the C statistic. Multivariate logistic regressions were performed to analyze the relevant risk factors. Among 1315 patients enrolled in study, previously unknown atrial fibrillation was detected in 110 (8.4%). Age, heart failure, NIHSS on admission, creatinine, and triglycerides were independently associated with newly detected atrial fibrillation. For newly detected atrial fibrillation, the C statistic value was 0.55 (OR 1.14, 95% CI: 0.97-1.33) for CHADS(2) and 0.62 (OR 1.26, 95% CI: 1.12-1.42) for CHA(2)DS(2)-VASc; adding newly identified risk factors to these two scores, the value of C statistic was improved to 0.74 and 0.75, respectively. Age, heart failure, NIHSS on admission, creatinine and triglycerides were independent predictors of previously unknown atrial fibrillation. The CHADS(2) and CHA(2)DS(2)-VASc scores are useful but not optimal for atrial fibrillation prediction. Addition of newly identified risk factors to these two scores resulted in significant improvement of the predictive performance. (C) 2018 Elsevier Ltd. All rights reserved.
基金：
Ministry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology, China [2011BAI08B02, 2012ZX09303, 2013BAI09B03]; Beijing Institute for Brain Disorders [BIBD-PXM2013_014226_07_000084]
第一作者机构：[a]Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[b]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[*1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing 100050, China.
推荐引用方式(GB/T 7714)：
Rixia Liu,Xiaomeng Yang,Shuya Li,et al.Modified CHADS(2) and CHA(2)DS(2)-VASc scores to predict atrial fibrillation in acute ischemic stroke patients[J].JOURNAL OF CLINICAL NEUROSCIENCE.2018,51:35-38.doi:10.1016/j.jocn.2018.02.016.
APA：
Rixia Liu,Xiaomeng Yang,Shuya Li,Yong Jiang,Yilong Wang&Yongjun Wang.(2018).Modified CHADS(2) and CHA(2)DS(2)-VASc scores to predict atrial fibrillation in acute ischemic stroke patients.JOURNAL OF CLINICAL NEUROSCIENCE,51,
MLA：
Rixia Liu,et al."Modified CHADS(2) and CHA(2)DS(2)-VASc scores to predict atrial fibrillation in acute ischemic stroke patients".JOURNAL OF CLINICAL NEUROSCIENCE 51.(2018):35-38
