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Quantitative Assessment of Invasion o High-Grade Gliomas Using Diffusion Tensor Magnetic Resonance Imaging

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收录情况： ◇ SCIE

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机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2]China National Clinical Research Center for Neurological Diseases, Beijing, China [3]Department of Neurosurgery, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China [4]Department of Radiology, Beijing Neurosurgical Institute, Beijing, China [5]Department of Electronic Engineering, Tsinghua University, Beijing, China [6]Health Management and Education Institute, Capital Medical University, Beijing, China

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关键词： Diffusion tensor imaging High-grade gliomas Invasive range

摘要：

OBJECTIVE: To determine heterogeneity of high-grade glioma (HGG) and its surrounding area and explore quantitative analysis of invasion of HGG using diffusion tensor imaging. METHODS: This study included 14 patients with HGG and preoperative magnetic resonance imaging and diffusion tensor imaging examinations. Three regions of interest were placed. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values of these regions of interest were measured, and specimens from the 3 regions of interest were obtained under navigation guidance. Postoperative examinations of specimens were carried out. Correlations between ADC and FA values and tumor cell density were evaluated. RESULTS: Median survival was 36.7 months. As distance from the tumor increased, the number of tumor cells significantly decreased. Regarding levels of matrix metalloproteinase-9 and Ki-67, only the differences between tumor and distances of 1 cm and 2 cm away from the tumor were statistically significant. For analysis of the relationship between tumor cell density and ADC and FA values, the discriminant formulas were as follows: G1 = -13.678 + 14984.791 (X) + 14443.847 (Y) (tumor cell density >= 10%); G2 = - 11.649 + 14443.847 (X) + 33.285 (Y) (tumor cell density <10%). CONCLUSIONS: We verified the heterogeneity of HGG and its surrounding area and found that patients with extensive resection may have longer survival. We also found a few formulas using FA and ADC values to predict tumor cell density.

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中科院(CAS)分区：

出版当年[2017]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区外科

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区外科

JCR分区：

出版当年[2016]版：

Q2 CLINICAL NEUROLOGY Q2 SURGERY

最新[2023]版：

Q2 SURGERY Q3 CLINICAL NEUROLOGY

影响因子： 1.9 最新[2023版] 2 最新五年平均 2.592 出版当年[2016版] 2.795 出版当年五年平均 2.685 出版前一年[2015版] 1.924 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2]China National Clinical Research Center for Neurological Diseases, Beijing, China

通讯作者：

通讯机构： [1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2]China National Clinical Research Center for Neurological Diseases, Beijing, China

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