机构：[1]Departments of Medical Laboratory, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China职能科室临床流行病与循证医学中心首都医科大学附属北京儿童医院[2] Departments of Neurology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China 临床科室职能科室临床流行病与循证医学中心泌尿外科首都医科大学附属北京儿童医院
Objective: To explore the incidence and independent risk-factors of secondary carnitine deficiency in Chinese children with epilepsy on valproate monotherapy. Methods: The free carnitine and acylcarnitines levels in 299 children with epilepsy on valproate monotherapy between June 2014 and September 2015 were compared with age-and sex-matched 299 healthy controls. Results: Children with valproate monotherapy had lower free carnitine levels [23.86 (10.60) mu mol/L] than the controls [36.37 (9.37) mu mol/L] (P<0.01). Most acylcarnitines were significantly lower in children with valproate monotherapy than controls. 63 children (21.1%) with epilepsy had carnitine deficiency; 54 were asymptomatic. Female gender (OR 2.1), high alanine aminotransferase levels (OR 1.0) and long duration of VPA treatment (1-12 mo) (OR 1.9) were independent risk factors for secondary carnitine deficiency induced by VPA. Conclusions: Carnitine deficiency with valproate is more likely in females, those with transaminitis, and those receiving the drug for 1-12 months.
基金：
Special Program for Capital Clinical Research of the Beijing municipal commission of science and technology; WU JIE PING medical foundation, China [Z121107005112008]
第一作者机构：[1]Departments of Medical Laboratory, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
通讯作者：
通讯机构：[1]Departments of Medical Laboratory, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China[*1]Department of Medical Laboratory, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, China.
推荐引用方式(GB/T 7714)：
Li Qiliang,Song Wenqi,Jin Hong.Carnitine Deficiency in Chinese Children with Epilepsy on Valproate Monotherapy[J].INDIAN PEDIATRICS.2018,55(3):222-+.doi:10.1007/s13312-018-1322-4.
APA：
Li Qiliang,Song Wenqi&Jin Hong.(2018).Carnitine Deficiency in Chinese Children with Epilepsy on Valproate Monotherapy.INDIAN PEDIATRICS,55,(3)
MLA：
Li Qiliang,et al."Carnitine Deficiency in Chinese Children with Epilepsy on Valproate Monotherapy".INDIAN PEDIATRICS 55..3(2018):222-+
