机构:[1]Guang’anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China,[2]Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China,[3]Department of Cardiology, Beijing Anzhen Hospital of the Capital University of Medical Sciences, Beijing, China,临床科室心脏内科中心首都医科大学附属安贞医院[4]Department of Pharmacology, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China,[5]Department of Pancreatic Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
Anthracyclines are effective agents generally used to treat solid-tumor and hematologic malignancies. The use of anthracyclines for over 40 years has improved cancer survival statistics. Nevertheless, the clinical utility of anthracyclines is limited by its dose-dependent cardiotoxicity that adversely affects 10-30% of patients. Anthracycline-induced cardiotoxicity may be classified as acute/subacute or chronic/late toxicity and leads to devastating adverse effects resulting in poor quality of life, morbidity, and premature mortality. Traditional Chinese medicine has a history of over 2,000 years, involving both unique theories and substantial experience. Several studies have investigated the potential of natural products to decrease the cardiotoxic effects of chemotherapeutic agents on healthy cells, without negatively affecting their antineoplastic activity. This article discusses the mechanism of anthracycline-induced cardiotoxicity, and summarizes traditional Chinese medicine treatment for anthracycline-induced heart failure (HF), cardiac arrhythmia, cardiomyopathy, and myocardial ischemia in recent years, in order to provide a reference for the clinical prevention and treatment of cardiac toxicity.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81725024, 81430098]; National high-level talent special support plan [W02020052]; Clinical base project of State Administration of traditional Chinese medicine of China [JDZX2015007]; outstanding project of Beijing University of Chinese Medicine [2015JYBXJQ001]
第一作者机构:[1]Guang’anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China,[2]Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China,
共同第一作者:
通讯作者:
通讯机构:[1]Guang’anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China,[2]Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China,[5]Department of Pancreatic Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
推荐引用方式(GB/T 7714):
Xinyu Yang,Nian Liu,Xinye Li,et al.A Review on the Effect of Traditional Chinese Medicine Against Anthracycline-Induced Cardiac Toxicity[J].FRONTIERS IN PHARMACOLOGY.2018,9(MAY):-.doi:10.3389/fphar.2018.00444.
APA:
Xinyu Yang,Nian Liu,Xinye Li,Yihan Yang,Xiaofeng Wang...&Hongcai Shang.(2018).A Review on the Effect of Traditional Chinese Medicine Against Anthracycline-Induced Cardiac Toxicity.FRONTIERS IN PHARMACOLOGY,9,(MAY)
MLA:
Xinyu Yang,et al."A Review on the Effect of Traditional Chinese Medicine Against Anthracycline-Induced Cardiac Toxicity".FRONTIERS IN PHARMACOLOGY 9..MAY(2018):-