机构：[1]Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China[2]Laboratory for Marine Drugs & Bioproducts, Qingdao National Laboratory for Marine Science & Technology, Qingdao, China[3]Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China[4]Department of Neurosurgery, Qilu Hospital of Shandong University, Qingdao, China[5]Shanghai Neuromedical Center, Qingdao University, Shanghai, China[6]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[7]Departmentof Neurosurgery, Qingdao University, Qingdao, China[8]Department ofChemistry, Bar-Ilan University, Ramat-Gan 52900, Israel[9]Department ofPharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China
Aim: To assess the effect of zinc-doped copper oxide nanocomposites (nZn-CuO NPs) on glioblastoma therapy. Materials & methods: nZn-CuO NPs were synthesized by sonochemical method and its antitumor effects and underlying molecular mechanisms were investigated both in vitro and in vivo. Results: After nZn-CuO NPs treatment, cell proliferation was significantly inhibited in dividing cancer cells but less toxicity was observed in normal cells. In vivo studies show that nZn-CuO NPs inhibited tumor growth in a dose-dependent manner. Further study found that nZn-CuO NPs trigger cell reactive oxygen species (ROS) generation and intrinsic apoptotic pathway. In temozolomide resistance glioblastoma, nZn-CuO NPs disturb cell growth and sphere formation by inhibiting AKT and ERK1/2 activation. Conclusion: nZn-CuO NPs possess the potential to be developed as a novel anti-tumor agent, especially to treat temozolomide resistance glioblastoma.
基金：
key research and development project of Shandong province [2016GSF115009]; key research program of Frontier Sciences, CAS [QYZDB-SSW-DQC014]; NSFC Shandong Provincial Natural Science Foundation [ZR2014HM004]; Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02, 2015ASTP]
第一作者机构：[1]Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China[2]Laboratory for Marine Drugs & Bioproducts, Qingdao National Laboratory for Marine Science & Technology, Qingdao, China[3]Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China
通讯作者：
通讯机构：[1]Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China[2]Laboratory for Marine Drugs & Bioproducts, Qingdao National Laboratory for Marine Science & Technology, Qingdao, China[3]Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China[9]Department ofPharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China
推荐引用方式(GB/T 7714)：
Wu Ning,Zhang Chunyun,Wang Changhui,et al.Zinc-doped copper oxide nanocomposites reverse temozolomide resistance in glioblastoma by inhibiting AKT and ERK1/2[J].NANOMEDICINE.2018,13(11):1303-1318.doi:10.2217/nnm-2017-0359.
APA：
Wu, Ning,Zhang, Chunyun,Wang, Changhui,Song, Lairong,Yao, Weicheng...&Shi, Dayong.(2018).Zinc-doped copper oxide nanocomposites reverse temozolomide resistance in glioblastoma by inhibiting AKT and ERK1/2.NANOMEDICINE,13,(11)
MLA：
Wu, Ning,et al."Zinc-doped copper oxide nanocomposites reverse temozolomide resistance in glioblastoma by inhibiting AKT and ERK1/2".NANOMEDICINE 13..11(2018):1303-1318
