机构：[1]Department of Obstetrics and Gynecology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China诊疗科室妇产科首都医科大学附属天坛医院[2]Beijing 302 Hospital, Beijing 100039, China
Gankyrin (also known as PSMD10 or p28GANK), engages in diverse biological processes, including cellular growth, proliferation and invasion. Several studies have demonstrated that Gankyrin is a candidate oncogene. In parallel, the dysregulation of Gankyrin has been observered in a variety of human cancer. Overexpression of Gankyrin is involved in tumor initiation and progression by regulating several signaling pathways that control cell-cycle process, cell growth, apoptosis, et al. On the contrary, downregulation of Gankyrin significantly inhibits cell growth, proliferation and metastasis. Therefore, Gankyrin appears to be a potential target for tumor therapy. Herein, this review summarizes the current knowledge in understanding the biological functions and oncogenic role of Gankyrin in human cancers from the perspective of clinical-pathological significances, aiming to provide guidance for the development of Gankyrin-targeted therapy.
基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [7184206]
第一作者机构：[1]Department of Obstetrics and Gynecology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Obstetrics and Gynecology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China[*1]Department of Obstetrics and Gynecology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
推荐引用方式(GB/T 7714)：
Li Haixai,Zhang Junyan,Zhen Cheng,et al.Gankyrin as a potential target for tumor therapy: evidence and perspectives[J].AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH.2018,10(7):1949-1960.
APA：
Li, Haixai,Zhang, Junyan,Zhen, Cheng,Yang, Baojun&Feng, Limin.(2018).Gankyrin as a potential target for tumor therapy: evidence and perspectives.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,10,(7)
MLA：
Li, Haixai,et al."Gankyrin as a potential target for tumor therapy: evidence and perspectives".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 10..7(2018):1949-1960
