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Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria

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收录情况： ◇ SCIE

作者：

机构： [1]Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [2]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China [3]Department of Clinical Laboratory, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, China [4]Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China

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关键词： Cancer therapy Tumor-associated bacteria Metabolites Drug delivery

摘要：

Emerging evidence reveal that tumor-associated bacteria (TAB) can facilitate the initiation and progression of multiple types of cancer. Recent work has emphasized the significant role of intestinal microbiota, particularly bacteria, plays in affecting responses to chemo- and immuno-therapies. Hence, it seems feasible to improve cancer treatment outcomes by targeting intestinal bacteria. While considering variable richness of the intestinal microbiota and diverse components among individuals, direct manipulating the gut microbiota is complicated in clinic. Tumor initiation and progression requires the gut microbiota-derived metabolites to contact and reprogram neoplastic cells. Hence, directly targeting tumor-associated bacteria metabolites may have the potential to provide alternative and innovative strategies to bypass the gut microbiota for cancer therapy. As such, there are great opportunities to explore holistic approaches that incorporates TAB-derived metabolites and related metabolic signals modulation for cancer therapy. In this review, we will focus on key opportunistic areas by targeting TAB-derived metabolites and related metabolic signals, but not bacteria itself, for cancer treatment, and elucidate future challenges that need to be addressed in this emerging field.Copyright © 2024 Elsevier B.V. All rights reserved.

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中科院(CAS)分区：

出版当年[2023]版中科院分区表Review为是的期刊

：

大类 | 1 区

医学

小类 | 1 区药学

最新[2023]版

：

大类 | 1 区

医学

小类 | 1 区药学

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出版当年[2022]版：

Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY

影响因子： 15.2 最新[2023版] 17.6 最新五年平均 16.1 出版当年[2022版] 17.7 出版当年五年平均 17.873 出版前一年[2021版] 15.2 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [2]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

通讯作者：

通讯机构： [2]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China [4]Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China

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