机构：[a]Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA[b]Department of Orthopedic Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, PR China首都医科大学附属天坛医院[c]Department of Neurosurgery, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA[d]Department of Engineering Science and Mechanics, Materials Research Institute, The Pennsylvania State University, University Park, PA 16802, USA
The mandate of folic acid supplementation in grained products has reduced the occurrence of neural tube defects by one third in the U.S since its introduction by the Food and Drug Administration in 1998. However, the advantages and possible mechanisms of action of using folic acid for peripheral nerve engineering and neurological diseases still remain largely elusive. Herein, folic acid is described as an inexpensive and multifunctional niche component that modulates behaviors in different cells in the nervous system. The multiple benefits of modulation include: 1) generating chemotactic responses on glial cells, 2) inducing neurotrophin release, and 3) stimulating neuronal differentiation of a PC-12 cell system. For the first time, folic acid is also shown to enhance cellular force generation and global methylation in the PC-12 cells, thereby enabling both biomechanical and biochemical pathways to regulate neuron differentiation. These findings are evaluated in vivo for clinical translation. Our results suggest that folic acid-nerve guidance conduits may offer significant benefits as a low-cost, off-the-shelf product for reaching the functional recovery seen with autografts in large sciatic nerve defects. Consequently, folic acid holds great potential as a critical and convenient therapeutic intervention for neural engineering, regenerative medicine, medical prosthetics, and drug delivery. (C) 2018 Elsevier Ltd. All rights reserved.
基金：
National Institutes of Health (USA)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [CA182670, HL118498]; National Science Foundation (USA) awardNational Science Foundation (NSF) [CMMI 1537008]; High Levels of Health Technical Personnel in Beijing City Health System (Beijing, China) [2013-3-050]
第一作者机构：[a]Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
通讯作者：
通讯机构：[a]Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA[b]Department of Orthopedic Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, PR China
推荐引用方式(GB/T 7714)：
Gloria B. Kim,Yongjie Chen,Weibo Kang,et al.The critical chemical and mechanical regulation of folic acid on neural engineering[J].BIOMATERIALS.2018,178:504-516.doi:10.1016/j.biomaterials.2018.03.059.
APA：
Gloria B. Kim,Yongjie Chen,Weibo Kang,Jinshan Guo,Russell Payne...&Jian Yang.(2018).The critical chemical and mechanical regulation of folic acid on neural engineering.BIOMATERIALS,178,
MLA：
Gloria B. Kim,et al."The critical chemical and mechanical regulation of folic acid on neural engineering".BIOMATERIALS 178.(2018):504-516
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