机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing 100500, China研究所北京市神经外科研究所首都医科大学附属天坛医院[2]Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China首都医科大学附属天坛医院[3]Key Laboratory of Central Nervous System Injury Research, Beijing Institute for Brain Disorders Brain Tumor Center, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing 100050, China
Currently, the primary therapeutic strategy for most growth hormone-producing pituitary adenomas (GHPA) is surgery. Due to the invasiveness of GHPA, high recurrence has limited the benefit of complete adenoma removal surgery. Epidermal growth factor-like domain 7 (EGFL7) is a secreted factor implicated in tumor angiogenesis, growth, invasiveness and metastasis in GHPA. Herein, we observed that the expression level of EGFL7 and p-EGFR in invasive GHPA was much higher than that of non-invasive GHPA. The overexpression of EGFL7 was positively correlated with activation of EGFR (p-EGFR). Noticeably, EGFL7 knockdown significantly inhibited activation of EGFR signaling cascades, including p-ERGR, p-AKT and p-ERK. Further studies showed that EGFL7 knockdown or pharmacological inhibition of EGFR-pathway, using EGFR inhibitor Tyrphostin AG-1478, significantly suppressed migration and invasion of GH3 and GT1-1 cells. In summary, our findings suggest that EGFL7 is a key factor for regulation of EGFR signaling pathway and plays an important role in migration and invasion of invasive GHPA.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81502154]; Research Special Fund For Public Welfare Industry of Health of China [201402008]; National High Technology Research and Development Program of ChinaNational High Technology Research and Development Program of China [2015AA020504]
第一作者机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing 100500, China[3]Key Laboratory of Central Nervous System Injury Research, Beijing Institute for Brain Disorders Brain Tumor Center, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing 100050, China
通讯作者：
通讯机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing 100500, China[2]Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China[3]Key Laboratory of Central Nervous System Injury Research, Beijing Institute for Brain Disorders Brain Tumor Center, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Qian Liu,Junwen Zhang,Hua Gao,et al.Role of EGFL7/EGFR-signaling pathway in migration and invasion of growth hormone-producing pituitary adenomas[J].SCIENCE CHINA-LIFE SCIENCES.2018,61(8):893-901.doi:10.1007/s11427-018-9320-4.
APA：
Qian Liu,Junwen Zhang,Hua Gao,Taoyang Yuan,Jie Kang...&Yazhuo Zhang.(2018).Role of EGFL7/EGFR-signaling pathway in migration and invasion of growth hormone-producing pituitary adenomas.SCIENCE CHINA-LIFE SCIENCES,61,(8)
MLA：
Qian Liu,et al."Role of EGFL7/EGFR-signaling pathway in migration and invasion of growth hormone-producing pituitary adenomas".SCIENCE CHINA-LIFE SCIENCES 61..8(2018):893-901
生物学