机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing, China研究所北京市神经外科研究所首都医科大学附属天坛医院[2]Key Laboratory of Central Nervous System Injury Research, Beijing Institute for Brain Disorders Brain Tumor Center, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China[3]Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China.[4]Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院
Invasiveness of growth hormone-producing pituitary adenomas (GHPAs) causes difficulties in safe and complete adenoma removal during surgery and often leads to high recurrence. Epidermal growth factor-like domain 7 (EGFL7) has been shown to be able to promote tumor angiogenesis, growth, invasiveness, and metastasis through the Notch signaling pathway. It was previously demonstrated that EGFL7 was overexpressed in GHPAs. This study reports that EGFL7 and Notch2 (positive correlation with EGFL7) are overexpressed in invasive GHPA. A long-rank test (Kaplan-Meier method) shows that invasive GHPAs with EGFL7 strong expression results in reduced recurrence-free survival. Multivariate Cox regression analysis reveals that weak EGFL7 expression is an independent prognostic factor for recurrence-free survival. In addition, knockdown of EGFL7 expression suppresses proliferation and invasion of GH3 and GT1-1 cells in vitro. Moreover, attenuation of EGFL7 inhibits human GHPA growth in vivo. The data suggest that as a Notch agonist, EGFL7 may potentially be an appropriate novel molecular target for future development of GHPA medical therapy.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81502154, 81602182]; Natural Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2016HP42, ZR2017MH077]; Research Special Fund for Public Welfare Industry of Health of China [201402008]; National High Technology Research and Development Program of China (863 Program)National High Technology Research and Development Program of China [2015AA020504]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区生物工程与应用微生物2 区遗传学2 区医学：研究与实验
最新[2023]版：
大类|3 区医学
小类|2 区生物工程与应用微生物3 区遗传学3 区医学：研究与实验
JCR分区：
出版当年[2016]版：
Q1BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ1MEDICINE, RESEARCH & EXPERIMENTALQ1GENETICS & HEREDITY
最新[2023]版：
Q1GENETICS & HEREDITYQ2BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing, China[2]Key Laboratory of Central Nervous System Injury Research, Beijing Institute for Brain Disorders Brain Tumor Center, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Neurosurgical Institute, Capital Medical University, Beijing, China[2]Key Laboratory of Central Nervous System Injury Research, Beijing Institute for Brain Disorders Brain Tumor Center, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China[4]Beijing Tiantan Hospital, Capital Medical University, Beijing, China[*1]Beijing Neurosurgical Institute, Capital Medical University, Beijing 10050, China.
推荐引用方式(GB/T 7714)：
Liu Qian,Wang Jianpeng,Yang Hongye,et al.Attenuation of EGFL7 Expression Inhibits Growth Hormone-Producing Pituitary Adenomas Growth and Invasion[J].HUMAN GENE THERAPY.2018,29(12):1396-1406.doi:10.1089/hum.2017.200.
APA：
Liu, Qian,Wang, Jianpeng,Yang, Hongye,Gao, Hua,Li, Chuzhong...&Zhang, Yazhuo.(2018).Attenuation of EGFL7 Expression Inhibits Growth Hormone-Producing Pituitary Adenomas Growth and Invasion.HUMAN GENE THERAPY,29,(12)
MLA：
Liu, Qian,et al."Attenuation of EGFL7 Expression Inhibits Growth Hormone-Producing Pituitary Adenomas Growth and Invasion".HUMAN GENE THERAPY 29..12(2018):1396-1406
