机构：[1]Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Department of Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China医技科室科研平台职能科室呼吸疾病研究室临床流行病与循证医学中心临床研究中心肿瘤与免疫研究室儿科研究所首都医科大学附属北京儿童医院[2]Department of Neonatology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China临床科室职能科室临床流行病与循证医学中心新生儿中心首都医科大学附属北京儿童医院[3]Department of Neonatology, Shunyi Women and Children’s Hospital of Beijing Children’s Hospital, Beijing, China.临床科室新生儿中心首都医科大学附属北京儿童医院
Background: To investigate the level of pertussis-related antibodies in pregnant women and newborns. Methods: A total of 286 serum samples from healthy pregnant women and 221 cord samples from newborns were collected in 2016 in Beijing. A routine blood sample from pregnant women was obtained at 35 weeks of gestational age, and cord samples were collected in 20 minutes after delivery. The values from cord samples were used as the infant values. Anti-pertussis toxin (PT) IgG concentration was measured by ELISA (Euroimmun, Lubeck, Germany) using purified PT as a coating antigen. Newborns with anti-PT IgG 40 IU/mL in cord samples were considered to be unprotected against pertussis. Anti-PT IgG 100 IU/mL was considered to be indicative of a recent pertussis infection in pregnant women. Results: The anti-PT IgG concentration below the lower limit of detection (<5 IU/mL) occurred in 74.1% (212/286) of pregnant women and 66.5% (147/221) of newborns. Even with detectable anti-PT antibodies, the majority of pregnant women (79.7%, 59/74) and newborns (73.0%, 54/74) had antibody level of 5 to <20 IU/mL, and 13.5% (10/74) of pregnant and 14.9% (11/74) of newborns had antibody level of 20 to <40 IU/mL. The 75% percentiles for anti-PT IgG of pregnant women and newborns were 5.08 and 6.98 IU/mL, respectively. The prevalence of unprotected newborns as defined by anti-PT IgG 40 IU/mL was 95.9% (202/211). The prevalence of recent pertussis infection in pregnant women as defined by anti-PT IgG 100 was 0.7% (2/286). Conclusions: The pregnant women and newborns were generally lack of protective antibody and are vulnerable to pertussis in Beijing, China. Although acellular pertussis vaccine is administrated in infancy in China, a booster vaccination to pregnant women should be considered for protecting young infants who are too young to start pertussis vaccination.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81701565]; Basic-Clinical Scientific Research Cooperation Fund of Capital Medical University [17JL55]
第一作者机构：[1]Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Department of Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Department of Microbiology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China[2]Department of Neonatology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China[*1]Department of Neonatology, Beijing Children’s Hospital, Capital Medical University, No. 56 Nan-li-shi Road, 100045 Beijing, China.[*2]Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, No. 56 Nan-li-shi Road, 100045 Beijing, China.
推荐引用方式(GB/T 7714)：
Meng Qing-hong,Luo Jie,Yang Fan,et al.A General Lack of IgG Against Pertussis Toxin in Chinese Pregnant Women and Newborns[J].PEDIATRIC INFECTIOUS DISEASE JOURNAL.2018,37(9):934-938.doi:10.1097/INF.0000000000001933.
APA：
Meng, Qing-hong,Luo, Jie,Yang, Fan,Shen, Ying-jie,Li, Li...&Yao, Kai-hu.(2018).A General Lack of IgG Against Pertussis Toxin in Chinese Pregnant Women and Newborns.PEDIATRIC INFECTIOUS DISEASE JOURNAL,37,(9)
MLA：
Meng, Qing-hong,et al."A General Lack of IgG Against Pertussis Toxin in Chinese Pregnant Women and Newborns".PEDIATRIC INFECTIOUS DISEASE JOURNAL 37..9(2018):934-938
