机构：[1]Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China医技科室科研平台职能科室呼吸疾病研究室临床流行病与循证医学中心临床研究中心儿科研究所首都医科大学附属北京儿童医院[2]Respiratory department, Qilu Children’s Hospital, Shandong University, Ji’nan 250022, China
Background: Vaccination is still one of the most important methods to control and prevent childhood infections including diphtheria and pertussis. This study evaluated the level of diphtheria (DT) and pertussis (PT)-related antibodies among children with pneumonia in Ji'nan, China. Methods: A total of 484 sera of children from 1day to 13years of age were collected from 2014 to 2015 in Ji'nan. Children with recent history of pertussis were excluded from this study. Anti-DT and PT IgG concentrations were measured by ELISA (Euroimmun, Lubeck, Germany). Results: Of the 484 subjects tested, the overall positivity rate of anti-DT IgG (0.1IU/ml) was 48.97%, and the highest positivity rate of anti-DT IgG (68.55%) and proportion with long term protection (23.27%) were observed in children aged 6 m- < 3 y. For anti-PT IgG, 334 subjects (69.01%) had anti-PT IgG levels below the lower limit of detection (5 IU/ml). Even with detectable anti-PT antibodies, the majority (115/150, 76.67%) of them had antibody levels of 5- < 40 IU/ml. The highest proportion of subjects with detectable anti-PT IgG (>= 5 IU/ml) was observed in children aged < 6 m (44.36%), then the proportion continually decreased to 15.0% at 3 y- < 6 y (chi(2) = 24.05, p < 0.0001). The highest positivity rate (>= 40IU/ml) was only 8.27% in children aged <6m. Subjects with an anti-PT IgG >= 100 IU/ml were observed in all the groups and there were no significant differences in the proportions of subjects with a level >= 100 IU/ml among these age groups (chi(2) = 2.572, p = 0.4624). A total of 5 subjects had anti-PT IgG >= 100 IU/ml (>= 1 years post pertussis vaccination) which was considered to be indicative of a recent pertussis infection. Conclusions: We demonstrated low antibody levels and protection against pertussis in our study population. The anti-PT IgG maintained a low level throughout all age groups, and even no immune responses were observed after the basic immunization and booster. Our study supported the need to reevaluate the immune response of DTP vaccine which was used in Shandong province after 2010.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81701565]; Ji'nan Medical and Health Science Technology Innovation Plan [201805015]; Basic-Clinical Scientific Research Cooperation Fund of Capital Medical University [17JL55]
第一作者机构：[1]Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China[2]Respiratory department, Qilu Children’s Hospital, Shandong University, Ji’nan 250022, China
推荐引用方式(GB/T 7714)：
Meng Qinghong,Li Lijun,Shi Wei,et al.Seroprevalence of diphtheria and pertussis immunoglobulin G among children with pneumonia in Ji'nan, China[J].BMC PEDIATRICS.2018,18(1):-.doi:10.1186/s12887-018-1337-y.
APA：
Meng, Qinghong,Li, Lijun,Shi, Wei,Wang, Qing,Ding, Mingjie...&Yao, Kaihu.(2018).Seroprevalence of diphtheria and pertussis immunoglobulin G among children with pneumonia in Ji'nan, China.BMC PEDIATRICS,18,(1)
MLA：
Meng, Qinghong,et al."Seroprevalence of diphtheria and pertussis immunoglobulin G among children with pneumonia in Ji'nan, China".BMC PEDIATRICS 18..1(2018):-
