机构：[1]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China[2]Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China[3]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经病学中心首都医科大学附属天坛医院[4]China National Clinical Research Center for Neurological Diseases, Beijing, China[5]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[6]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
Objective: This study aimed to investigate the association between the hemoglobin glycation index (HGI) and the prognosis of diabetic patients with ischemic stroke. Methods: Data were derived from the Abnormal Glucose Regulation in Patients with Acute Stroke across China (ACROSS-China) registry. Diabetic patients with ischemic stroke were included. HGI was calculated by subtracting the predicted HbA1c based on fasting plasma glucose from the observed HbA1c, and then classified into three groups by the tertiles: low HGI (<-0.62), moderate HGI (-0.62 to 0.35) and high HGI (0.36). Outcomes included stroke recurrence, all-cause death and poor outcome at 12months. Results: A total of 976 diabetic patients were included. Low HGI was associated with an increased risk of stroke recurrence and poor outcome (adj.hazard ratio 1.53, 95% confidence intervals (CIs) 1.11-2.12, p=0.01; and adj.odds ratio 1.64, 95% CI 1.13-2.38, p=0.01, respectively), and high HGI was associated with an increased risk of poor outcome (adj.odds ratio 1.54, 95% CI 1.06-2.24, p=0.02), compared with moderate HGI. We found a U-shaped association between HGI and the prognosis. Conclusion: Both low HGI and high HGI was associated with an increased risk of poor prognosis in diabetic patients with ischemic stroke, compared with moderate HGI.
基金：
Ministry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology, China [2015BAI12B04, 2015BAI12B02, 2016YFC0901000, 2016YFC0901001, 2016YFC0901002]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31672375]; Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [Z15110200390000, Z151100003915117]; Beijing Municipal Commission of Health and Family Planning [2016-1-2041, SML20150502]
第一作者机构：[1]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China[2]Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China[3]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China[2]Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China[3]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[4]China National Clinical Research Center for Neurological Diseases, Beijing, China[5]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[6]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
推荐引用方式(GB/T 7714)：
Pan Yuesong,Jing Jing,Wang Yongjun,et al.Association of hemoglobin glycation index with outcomes of acute ischemic stroke in type 2 diabetic patients[J].NEUROLOGICAL RESEARCH.2018,40(7):575-582.doi:10.1080/01616412.2018.1453991.
APA：
Pan, Yuesong,Jing, Jing,Wang, Yongjun,Liu, Liping,Wang, Yilong&He, Yan.(2018).Association of hemoglobin glycation index with outcomes of acute ischemic stroke in type 2 diabetic patients.NEUROLOGICAL RESEARCH,40,(7)
MLA：
Pan, Yuesong,et al."Association of hemoglobin glycation index with outcomes of acute ischemic stroke in type 2 diabetic patients".NEUROLOGICAL RESEARCH 40..7(2018):575-582
