机构：[a]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[b]Department of Internal Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[c]Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[d]Department of Physiology, Capital Medical University, Beijing, China[e]Center for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[f]China National Clinical Research Center for Neurological Diseases, Beijing, China[g]Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, China[h]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, China[i]Beijing Key Laboratory on Parkinson’s Disease, Beijing, China
Background: OD is common in patients with Alzheimer's disease (AD). However, the relationship between OD and clinical symptoms and the potential mechanisms of OD in AD patients are still unknown. Objective: To explore the relationship between OD and clinical symptoms and the potential mechanisms of OD in AD patients. Methods: We evaluated OD using the Hyposmia Rating Scale (HRS), classified patients into AD with OD (AD-OD) and AD with no OD (AD-NOD) groups, and detected the levels of free radicals and inflammatory factors, including hydroxyl radical (center dot OH), hydrogen peroxide (H2O2), nitric oxide, interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, and prostaglandin E-2 in serum from AD patients. Results: It was shown that the scores of the Mini-Mental State Examination, Animal Fluency Test, Boston Naming Test (BNT), and Auditory Verbal Learning Test-delayed recall were all significantly lower and the score of overall activity of daily living (ADL) and instrumental ADL were significantly higher in AD-OD group than those in AD-NOD group. Compared with AD-NOD group, center dot OH level in serum was prominently elevated, and H2O2 level was dramatically declined in AD-OD group. In the correlation analysis, HRS score was significantly and positively correlated with the score of BNT, and negatively correlated with center dot OH level in serum. Conclusions: AD-OD patients suffered from severe cognitive impairment in the domain of language. Oxidative stress might be correlated with AD-OD featured by the drastically increased center dot OH level in serum.
基金：
National Key Research and Development Program of China [2016 YFC1306300, 2016YFC1306000]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81571229, 81071015, 30770745]; Key Project of National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81030062]; Key Project of Natural Science Foundation of Beijing, China [kz201610025030, 4161004, kz200910025001]; Natural Science Foundation of Beijing, ChinaBeijing Natural Science Foundation [7082032]; Project of Scientific and Technological Development of Traditional Chinese Medicine in Beijing [JJ201848]; National Key Basic Research Program of ChinaNational Basic Research Program of China [2011CB504100]; Important National Science & Technology Specific Projects [2011ZX09102-003-01]; National Key Technology Research and Development Program of the Ministry of Science and Technology of ChinaNational Key Technology R&D Program [2013BAI09B03]; Project of Beijing Institute for Brain Disorders [BIBD-PXM 2013_014226_07_000084]; High Level Technical Personnel Training Project of Beijing Health System, China [2009-3-26]; Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges Under Beijing Municipality [IDHT20140514]; Capital Clinical Characteristic Application Research [Z12110700100 000, Z121107001012161]; Beijing Healthcare Research Project, China [JING-15-2, JING-15-3]; Excellent Personnel Training Project of Beijing, China [20071D0300400076]; Basic-Clinical Research Cooperation Funding of Capital Medical University, China [2015-JL-PT-X04, 10JL49, 14JL15]; Youth Research Funding, Beijing Tiantan Hospital, Capital Medical University, China [2014-YQN-YS-18, 2015-YQN-15, 2015-YQN-05, 2015-YQN-14, 2015-YQN-17]
第一作者机构：[a]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[e]Center for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[f]China National Clinical Research Center for Neurological Diseases, Beijing, China[g]Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, China[h]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, China[i]Beijing Key Laboratory on Parkinson’s Disease, Beijing, China[*1]Center for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
推荐引用方式(GB/T 7714)：
Zuo Li-jun,Guo Peng,Liu Li,et al.Analyses of Clinical Features and Investigations on Potential Mechanisms in Patients with Alzheimer's Disease and Olfactory Dysfunction[J].JOURNAL OF ALZHEIMERS DISEASE.2018,66(2):789-799.doi:10.3233/JAD-180425.
APA：
Zuo, Li-jun,Guo, Peng,Liu, Li,Yu, Shu-yang,Lian, Teng-hong...&Zhang, Wei.(2018).Analyses of Clinical Features and Investigations on Potential Mechanisms in Patients with Alzheimer's Disease and Olfactory Dysfunction.JOURNAL OF ALZHEIMERS DISEASE,66,(2)
MLA：
Zuo, Li-jun,et al."Analyses of Clinical Features and Investigations on Potential Mechanisms in Patients with Alzheimer's Disease and Olfactory Dysfunction".JOURNAL OF ALZHEIMERS DISEASE 66..2(2018):789-799
