国家科技支撑计划(2013BAI09B11)%首都医科大学基础-临床科研合作基金(重点14JL06)%首都卫生发展科研专项(首发2014-1-2094)National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2013BAI09B11)%Clinical Research of Capital Medical University(key program 14JL06)%Capital Health Research and Development of Special(2014-1-2094)