Out of 12 nontuberculous mycobacteria (NTM) species, 5 were identified as Mycobacterium tuberculosis (MTB) by GeneXpert at a bacterial load of 10(6). Notably, two species, including M. abscessus and M. smegmatis, were flagged as RIF-resistant MTB due to the high C(t) value of Probe E. In conclusion, our data have demonstrated that the misdiagnosis of MTB by GeneXpert assay is observed in five NTM species at a high bacterial load.
基金:
Major State Basic Research Development Program of ChinaNational Basic Research Program of China [2014CB744403]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81401739]
第一作者机构:[1]Capital Med Univ, Natl TB Clin Lab, Beijing Key Lab Drug Resistance TB Res, Beijing TB & Thorac Tumor Res Ins,Beijing Chest, 97 Machang, Beijing 101149, Peoples R China;
通讯作者:
通讯机构:[1]Capital Med Univ, Natl TB Clin Lab, Beijing Key Lab Drug Resistance TB Res, Beijing TB & Thorac Tumor Res Ins,Beijing Chest, 97 Machang, Beijing 101149, Peoples R China;[4]Chinese Ctr Dis Control & Prevent, Natl Ctr TB Control & Prevent, 155 Chang Bai Rd, Beijing 102206, Peoples R China
推荐引用方式(GB/T 7714):
Pang Yu,Lu Jie,Su Biyi,et al.Misdiagnosis of tuberculosis associated with some species of nontuberculous mycobacteria by GeneXpert MTB/RIF assay[J].INFECTION.2017,45(5):677-681.doi:10.1007/s15010-017-1044-x.
APA:
Pang, Yu,Lu, Jie,Su, Biyi,Zheng, Huiwen&Zhao, Yanlin.(2017).Misdiagnosis of tuberculosis associated with some species of nontuberculous mycobacteria by GeneXpert MTB/RIF assay.INFECTION,45,(5)
MLA:
Pang, Yu,et al."Misdiagnosis of tuberculosis associated with some species of nontuberculous mycobacteria by GeneXpert MTB/RIF assay".INFECTION 45..5(2017):677-681