机构：[1]Qingdao Chengyang Peoples Hosp, Dept Neurosurg, Qingdao 266106, Peoples R China;[2]Ningxia Med Univ, Dept Neurosurg, Gen Hosp, Ningxia Key Lab Cerebrocranial Dis, Yinchuan 750004, Peoples R China;[3]Ningxia Med Univ, Dept Cardiac Funct Examinat, Gen Hosp, Yinchuan, Peoples R China;[4]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China;重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[5]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;国家神经系统疾病临床医学研究中心国家神经系统疾病临床医学研究中心首都医科大学附属天坛医院[6]Capital Med Univ, Beijing Tiantan Hosp, Monogen Dis Res Ctr Neurol Disorders, Beijing, Peoples R China;重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[7]Ningxia Med Univ, Yinchuan, Peoples R China;[8]8th Peoples Hosp Qingdao City, Qingdao, Peoples R China;[9]Ningxia Med Univ, Dept Neurosurg, Gen Hosp, Ningxia Key Lab Cerebrocranial Dis, 804 Shenglinajie, Ningxia 750004, Peoples R China;[10]Ningxia Med Univ, Dept Cardiac Funct Examinat, Gen Hosp, 804 Shenglinajie, Ningxia 750004, Peoples R China
This study is to clarify the protective role of alpha-lipoic acid in high-fat diet-induced cerebral damage mice. The mice were divided into 5 groups: normal control group, high-fat diet (HFD) group, low-dose alpha-lipoic acid group for prevention, high-dose alpha-lipoic acid group for prevention, and high-dose alpha-lipoic acid group for treatment. The groups' weights and blood glucose changes were monitored. We used HE staining to observe morphological changes in the cerebral cortex. The expression levels of the oxidative stress proteins SOD2, catalase, and the inflammatory pathway proteins p-JNK, p-ERK were measured by western blot and immunochemistry. Compared with the control group, the quantity of cortical neurons in the HFD group was decreased, and the samples exhibited retrogression. However, the lipoic acid significantly protected and promoted the cortical neurons survival. Moreover, compared with the HFD group, the expression levels of SOD2 and catalase in the three alpha-lipoic acid obtained groups were significantly increased. However, the expression levels of the inflammatory pathway proteins p-JNK and p-ERK were significantly decreased. These results indicate that the alpha-lipoic acid greatly protects the cortical neurons, and inhibited the oxidative stress and inflammatory reactions in the high fat diet mice.
基金：
National Nature Science Foundation of ChinaNational Natural Science Foundation of China [81360183]; Nature Science Foundation of NingXia
通讯机构：[2]Ningxia Med Univ, Dept Neurosurg, Gen Hosp, Ningxia Key Lab Cerebrocranial Dis, Yinchuan 750004, Peoples R China;[3]Ningxia Med Univ, Dept Cardiac Funct Examinat, Gen Hosp, Yinchuan, Peoples R China;[9]Ningxia Med Univ, Dept Neurosurg, Gen Hosp, Ningxia Key Lab Cerebrocranial Dis, 804 Shenglinajie, Ningxia 750004, Peoples R China;[10]Ningxia Med Univ, Dept Cardiac Funct Examinat, Gen Hosp, 804 Shenglinajie, Ningxia 750004, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Yang,Zhang Qinghua,Wang Li,et al.The alpha-lipoic acid improves high-fat diet-induced cerebral damage through inhibition of oxidative stress and inflammatory reaction[J].ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY.2017,56:219-224.doi:10.1016/j.etap.2017.09.018.
APA：
Liu, Yang,Zhang, Qinghua,Wang, Li,Wang, Hui,Sun, Tao...&Zhang, Li.(2017).The alpha-lipoic acid improves high-fat diet-induced cerebral damage through inhibition of oxidative stress and inflammatory reaction.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,56,
MLA：
Liu, Yang,et al."The alpha-lipoic acid improves high-fat diet-induced cerebral damage through inhibition of oxidative stress and inflammatory reaction".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 56.(2017):219-224
