Osteopontin (OPN) has been investigated in the field of tumor research for several years. However, the prognostic role of OPN over-expression in acute myeloid leukemia (AML) remains controversial. A meta-analysis of four studies, including a total of 492 patients, was performed to determine the association of OPN with overall survival (OS) in AML patients. The random-effects model of Der Simonian and Laird was used to synthesize data; hazard ratio (HR) with its 95% confidence interval (CI) was used as the effect size estimate. It was observed that serum-based OPN was inversely correlated with OS and the difference was statistically significant (HR=1.83; 95% CI: 1.43-2.35; P<0.001). Experimental findings indicate that OPN over-expression is associated with a poor prognosis in AML and may be of prognostic value for AML stage and metastasis.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81641006]; Beijing City Youth Top-Notch Talents Project [2016000021223ZK16]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
无
最新[2025]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]PLA Army Gen Hosp, Dept Hepatobiliary Surg, Beijing 100700, Peoples R China;
通讯作者：
通讯机构：[3]Capital Med Univ, Beijing Childrens Hosp, Hematol Oncol Ctr,Beijing Key Lab Pediat Hematol, Minist Educ,Key Lab Major Dis Children,Natl Key D, 56 Nanlishi Rd, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Chen Yong-Bing,Ren Si-Mei,Li Si-Dan,et al.Prognostic significance of osteopontin in acute myeloid leukemia: A meta-analysis[J].MOLECULAR AND CLINICAL ONCOLOGY.2017,7(2):275-280.doi:10.3892/mco.2017.1302.
APA：
Chen, Yong-Bing,Ren, Si-Mei,Li, Si-Dan&Du, Zhongli.(2017).Prognostic significance of osteopontin in acute myeloid leukemia: A meta-analysis.MOLECULAR AND CLINICAL ONCOLOGY,7,(2)
MLA：
Chen, Yong-Bing,et al."Prognostic significance of osteopontin in acute myeloid leukemia: A meta-analysis".MOLECULAR AND CLINICAL ONCOLOGY 7..2(2017):275-280
