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Bovine lactoferricin P13 triggers ROS-mediated caspase-dependent apoptosis in SMMC7721 cells

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收录情况： ◇ SCIE

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机构： [1]Anhui Med Univ, Affiliated Prov Hosp, Dept Hepat Surg, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China; [2]Anhui Med Univ, Affiliated Prov Hosp, Anhui Prov Key Lab Hepatopancreatobiliary Surg, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China; [3]Beijing Childrens Hosp Grp, Anhui Prov Childrens Hosp, Dept Gen Surg, Hefei 230051, Anhui, Peoples R China

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关键词： bovine lactoferricin P13 hepatocellular carcinoma apoptosis reactive oxygen species caspase-3 caspase-9

摘要：

Bovine lactoferricin P13 (LfcinB-P13) is a peptide derived from LfcinB. In the present study, the effect of LfcinB-P13 on the human liver cancer cell line SMMC7721 was investigated in vitro and in vivo. The results of the present study indicate that LfcinB-P13 significantly decreased SMMC7721 cell viability in vitro (P=0.032 vs. untreated cells), while exhibiting low cytotoxicity in the wild-type liver cell line L02. In addition, the rate of apoptosis in SMMC7721 cells was significantly increased following treatment with 40 and 60 mu g/ml LfcinB-P13 (P=0.0053 vs. the control group), which was associated with an increase in the level of reactive oxygen species (ROS) and the activation of caspase-3 and-9. Furthermore, ROS chelation led to the suppression of LfcinB-P13-mediated caspase-3 and-9 activation in SMMC7721 cells. LfcinB-P13 was demonstrated to markedly inhibit tumor growth in an SMMC7721-xenograft nude mouse model. The results of the present study indicate that LfcinB-P13 is a novel candidate therapeutic agent for the treatment of liver cancer.

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出版当年[2016]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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出版当年[2015]版：

Q4 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 2.5 最新[2023版] 2.4 最新五年平均 1.482 出版当年[2015版] 1.448 出版当年五年平均 1.554 出版前一年[2014版] 1.39 出版后一年[2016版]

第一作者：

第一作者机构： [1]Anhui Med Univ, Affiliated Prov Hosp, Dept Hepat Surg, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China; [2]Anhui Med Univ, Affiliated Prov Hosp, Anhui Prov Key Lab Hepatopancreatobiliary Surg, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China; [3]Beijing Childrens Hosp Grp, Anhui Prov Childrens Hosp, Dept Gen Surg, Hefei 230051, Anhui, Peoples R China

通讯作者：

通讯机构： [1]Anhui Med Univ, Affiliated Prov Hosp, Dept Hepat Surg, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China; [2]Anhui Med Univ, Affiliated Prov Hosp, Anhui Prov Key Lab Hepatopancreatobiliary Surg, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China;

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