Monocytes play important roles in antigen presentation and cytokine production to achieve a proper immune response, and are therefore largely implicated in the development and progression of autoimmune diseases. The aim of this study was to analyze the change in the intermediate (CD14+ CD16+) monocyte subset in children with recent-onset type 1 diabetes mellitus (TIDM) and its possible association with clinical parameters reflecting islet beta-cell dysfunction. Compared with age-and sex-matched healthy controls, intermediate monocytes were expanded in children with TIDM, which was positively associated with hemoglobin A1C and negatively associated with serum insulin and C-peptide. Interestingly, the intermediate monocytes in TIDM patients expressed higher levels of human leukocyte antigen-DR and CD86, suggesting better antigen presentation capability. Further analysis revealed that the frequency of CD45RO+ CD4+ memory T cells was increased in the TIDM patients, and the memory T cell content was well correlated with the increase in intermediate monocytes. These results suggest that expanded intermediate monocytes are a predictive factor for the poor residual islet beta-cell function in children with recent-onset TIDM.
基金：
Beijing Children's Hospital, a teaching hospital affiliated to Capital Medical University; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31470862]
第一作者机构：[1]Capital Med Univ, Beijing Childrens Hosp, Minist Educ, Key Lab Major Dis Children, Beijing, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Dept Endocrinol Genet & Metab, Beijing 100045, Peoples R China;[3]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Immunol Lab, Beijing 100045, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Childrens Hosp, Minist Educ, Key Lab Major Dis Children, Beijing, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Dept Endocrinol Genet & Metab, Beijing 100045, Peoples R China;[3]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Immunol Lab, Beijing 100045, Peoples R China;
推荐引用方式(GB/T 7714)：
Ren Xiaoya,Mou Wenjun,Su Chang,et al.Increase in Peripheral Blood Intermediate Monocytes is Associated with the Development of Recent-Onset Type 1 Diabetes Mellitus in Children[J].INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES.2017,13(2):209-218.doi:10.7150/ijbs.15659.
APA：
Ren, Xiaoya,Mou, Wenjun,Su, Chang,Chen, Xi,Zhang, Hui...&Gong, Chunxiu.(2017).Increase in Peripheral Blood Intermediate Monocytes is Associated with the Development of Recent-Onset Type 1 Diabetes Mellitus in Children.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,13,(2)
MLA：
Ren, Xiaoya,et al."Increase in Peripheral Blood Intermediate Monocytes is Associated with the Development of Recent-Onset Type 1 Diabetes Mellitus in Children".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 13..2(2017):209-218
生物学