ObjectiveThe purpose of this study was to determine the airway resistance in Chinese children with obstructive sleep apnea hypopnea syndrome (OSAHS) by impulse oscilloetry (IOS) and investigate the association of the severity of OSAHS with the airway resistance and allergic sensitization. MethodA total of 120 children (92 boys) treated for snoring in Beijing Children's Hospital between October 2010 and March 2011 were included in this study. Ninety-three children were diagnosed with OSAHS and 27 did not show OSAHS. Total airway resistance (R5), proximal airway resistance (R20), and peripheral airway resistance (X5) were determined by IOS. Serum levels of total IgE and allergen-specific IgE (sIgE) were also determined. ResultsR5 in the OSAHS group was significantly higher than that in the non-OSAHS group (P=0.0025), whereas R20 and X5 were similar in the two groups. R5 was positively correlated with apnea hypopnea index and obstructive apnea index and negatively correlated with the lowest arterial oxygen saturation significantly (all P<0.05). The percentage of children with abnormal serum levels of total IgE or abnormal allergen-specific IgEs was comparable in OSAHS and non-OSAHS groups. The proportions of abnormal R5 and of abnormal serum levels of total IgE were significantly higher in children with severe OSAHS compared with children with mild or moderate OSAHS (all P<0.05). ConclusionsTotal airway resistance was significantly increased in Children with OSAHS. Allergic sensitization might contribute to the exacerbation of existing OSAHS in children. Large scale studies are required to further validate these findings. Pediatr Pulmonol. 2016;51:426-430. (c) 2015 Wiley Periodicals, Inc.
基金：
Beijing Municipal Science and Technology Project of Children's Health [Z13110006813044]; Scientific Research Project of Capital Health Development [2014-1-2091]
第一作者机构：[1]Capital Med Univ, Head & Neck Surg Beijing Pediat Res Inst, Beijing Key Lab Pediat Dis Otolaryngol, Dept Otorhinolaryngol,Beijing Childrens Hosp, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Head & Neck Surg Beijing Pediat Res Inst, Beijing Key Lab Pediat Dis Otolaryngol, Dept Otorhinolaryngol,Beijing Childrens Hosp, Beijing, Peoples R China;[3]Capital Med Univ, Beijing Childrens Hosp, Dept Otorhinolaryngol, 56 Nanlishi Rd, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Jie,Zhao Jing,Chen Min,et al.Airway resistance and allergic sensitization in children with obstructive sleep apnea hypopnea syndrome[J].PEDIATRIC PULMONOLOGY.2016,51(4):426-430.doi:10.1002/ppul.23264.
APA：
Zhang, Jie,Zhao, Jing,Chen, Min,Liu, Shilin,Zhang, Xuexi...&Ni, Xin.(2016).Airway resistance and allergic sensitization in children with obstructive sleep apnea hypopnea syndrome.PEDIATRIC PULMONOLOGY,51,(4)
MLA：
Zhang, Jie,et al."Airway resistance and allergic sensitization in children with obstructive sleep apnea hypopnea syndrome".PEDIATRIC PULMONOLOGY 51..4(2016):426-430
