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Tenuigenin exhibits protective effects against LPS-induced acute kidney injury via inhibiting TLR4/NF-kappa B signaling pathway

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收录情况： ◇ SCIE

作者：
Fu, Haiyan[1,5] * ; Hu, Zhansheng[1] ; Di, Xingwei[1] ; Zhang, Qiuhong[2] ; Zhou, Rongbin[3] ; Du, Hongyang[4] ;
机构： [1]Jinzhou Med Univ, Affiliated Hosp 1, Intens Care Unit, Jinzhou 121000, Liaoning, Peoples R China; [2]Second Hosp Chaoyang, Med Examinat Ctr, Chaoyan 122000, Liaoning, Peoples R China; [3]Mil Gen Hosp Beijing PLA, Emergency Dept, Beijing 100700, Peoples R China; [4]Jinzhou Med Univ, Affiliated Hosp 1, Dept Dermatol, Jinzhou 121000, Peoples R China; [5]Capital Med Univ, Beijing Childrens Hosp, Dept Dermatol, Beijing 100045, Peoples R China
出处：
DOI： 10.1016/j.ejphar.2016.08.013
ISSN：

关键词： Acute kidney injury Tenuigenin LPS NF-kappa B

摘要：
Tenuigenin (TNG) has been reported to have various pharmacological activities, such as anti-oxidative and anti-inflammatory activities. However, the protective effects of TNG on lipopolysaccharides (LPS)induced acute kidney injury (AKI) are still not clear. The aim of this study was to investigate the protective effects and mechanism of TGN on LPS-induced AKI in mice. The kidney histological change, levels of blood urea nitrogen (BUN), and creatinine were measured to assess the protective effects of TNG on LPS-induced AKI. The levels of TNIF-alpha, IL-1 beta, and IL-6 in serum and kidney tissues were detected by ELISA. The extent of nuclear factor kappa-B (NF-kappa B) p65 and the expression of Toll-like receptor-4 (TLR4) were detected by western blot analysis. The results showed that TNG markedly attenuated the histological alterations, BUN and creatinine levels in kidney. TNG also suppressed LPS-induced TNIF-alpha, IL-1 beta, and IL-6 production. Furthermore, the expression of TLR4 and NF-kappa B activation induced by LPS were markedly inhibited by TNG. In conclusion, this study demonstrated that TNG protected against LPS-induced AKI by inhibiting TLR4/NF-kappa B signaling pathway. (C) 2016 Elsevier B.V. All rights reserved.

基金：
Beijing Natural Science Foundation of ChinaBeijing Natural Science Foundation [7163224]; National Science Foundation for Postdoctoral Scientists of China(CPSF) [2015M572776]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类 | 3 区 医学
小类 | 3 区 药学
最新[2023]版：
大类 | 3 区 医学
小类 | 2 区 药学
JCR分区：
出版当年[2014]版：
Q2 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

第一作者：
第一作者机构： [1]Jinzhou Med Univ, Affiliated Hosp 1, Intens Care Unit, Jinzhou 121000, Liaoning, Peoples R China; [5]Capital Med Univ, Beijing Childrens Hosp, Dept Dermatol, Beijing 100045, Peoples R China
通讯作者：
通讯机构： [4]Jinzhou Med Univ, Affiliated Hosp 1, Dept Dermatol, Jinzhou 121000, Peoples R China;
推荐引用方式(GB/T 7714)：
Fu Haiyan,Hu Zhansheng,Di Xingwei,et al.Tenuigenin exhibits protective effects against LPS-induced acute kidney injury via inhibiting TLR4/NF-kappa B signaling pathway[J].EUROPEAN JOURNAL OF PHARMACOLOGY.2016,791:229-234.doi:10.1016/j.ejphar.2016.08.013.
APA：
Fu, Haiyan,Hu, Zhansheng,Di, Xingwei,Zhang, Qiuhong,Zhou, Rongbin&Du, Hongyang.(2016).Tenuigenin exhibits protective effects against LPS-induced acute kidney injury via inhibiting TLR4/NF-kappa B signaling pathway.EUROPEAN JOURNAL OF PHARMACOLOGY,791,
MLA：
Fu, Haiyan,et al."Tenuigenin exhibits protective effects against LPS-induced acute kidney injury via inhibiting TLR4/NF-kappa B signaling pathway".EUROPEAN JOURNAL OF PHARMACOLOGY 791.(2016):229-234

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