RhBMP-2 has shown great promise for the reconstruction of teeth segmental bone defects due to its osteoinductive properties. But the application of rhBMP-2 is limited by its weak drug controled release. It is usually loaded in a Chitosan Microspheres (CMs) delivery system with excess single cross-linker and then removed before practice. In this study, cross-linkers were replaced with RhBMP-2 which contains vanillin and vitriolic acid, and thus CMs were developed. The materials were studied by SEM, FTIR and drug release experiments. It showed an ideal releasing profile and excellent osteoconductive and osteoinductive performance in the delivery system. Therefore, designing biomaterials with a controllable delivery system composite and releasing profile of rhBMP-2 are critical for applications of bone regeneration and tissue engineering.
基金：
Beijing municipal science and technology project [Z151100003715006]; National Basic Research Program of China (973 program)National Basic Research Program of China [2011CB710901]; National Key Technology RD ProgramNational Key Technology R&D Program [2014BAI11B15, 2012BAI18B06, 2012BAI18B05]; 111 Project of China [B13003]; capital health research and development of special fund [2014-1-2091]; Beijing Municipal Administration of Hospitals clinical medicine development of special fund [ZYLX201508]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区牙科与口腔外科4 区材料科学：生物材料
最新[2023]版：
大类|4 区医学
小类|4 区牙科与口腔外科4 区材料科学：生物材料
JCR分区：
出版当年[2014]版：
Q3DENTISTRY, ORAL SURGERY & MEDICINEQ4MATERIALS SCIENCE, BIOMATERIALS
最新[2023]版：
Q2DENTISTRY, ORAL SURGERY & MEDICINEQ4MATERIALS SCIENCE, BIOMATERIALS
第一作者机构：[1]Beihang Univ, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechanobiol, Minist Educ, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Beihang Univ, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechanobiol, Minist Educ, Beijing, Peoples R China;
推荐引用方式(GB/T 7714)：
Zhou Gang,Yu Xin,Tai Jun,et al.Research on a novel chitosan microsphere/scaffold system by double cross-linkers[J].DENTAL MATERIALS JOURNAL.2016,35(6):862-868.doi:10.4012/dmj.2015-227.
APA：
Zhou, Gang,Yu, Xin,Tai, Jun,Han, Fengyu,Yan, Ming...&Fan, Yubo.(2016).Research on a novel chitosan microsphere/scaffold system by double cross-linkers.DENTAL MATERIALS JOURNAL,35,(6)
MLA：
Zhou, Gang,et al."Research on a novel chitosan microsphere/scaffold system by double cross-linkers".DENTAL MATERIALS JOURNAL 35..6(2016):862-868
