Cattle encephalon glycoside and ignotin injection promoted synthesis of glial cell line-derived neurotrophic factor by astrocytes that protected against neuronal damage induced by AAPH
Cattle encephalon glycoside and ignotin injection offers neural protection after cerebral apoplexy clinically, but the exact mechanism of the protective effect is unclear. We performed primary culture of neurons and astrocytes and simulated ischemic brain damage using AAPH and discussed the action mechanism of cattle encephalon glycoside and ignotin injection. Results showed that cattle encephalon glycoside and ignotin injection was effective against the neuronal damage induced by AAPH through promoting the secretion of glial cell line-derived neurotrophic factor (GDNF) by the astrocytes.
基金：
National Natural Science FoundationNational Natural Science Foundation of China [81171097, 8127-1312]
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Lab Clin Med Res, Beijing 100050, Peoples R China;[3]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;[4]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China;[5]Beijing Key Lab Translat Med Cerebrovascular Dis, Beijing, Peoples R China
通讯作者：
通讯机构：[2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, 6 Tiantan Xili, Beijing 100050, Peoples R China;[3]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;[4]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China;[5]Beijing Key Lab Translat Med Cerebrovascular Dis, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Guo An-Chen,Zhao Yi-Long,Wang Yong-Jun,et al.Cattle encephalon glycoside and ignotin injection promoted synthesis of glial cell line-derived neurotrophic factor by astrocytes that protected against neuronal damage induced by AAPH[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2016,9(2):1794-1800.
APA：
Guo, An-Chen,Zhao, Yi-Long,Wang, Yong-Jun&Wang, Qun.(2016).Cattle encephalon glycoside and ignotin injection promoted synthesis of glial cell line-derived neurotrophic factor by astrocytes that protected against neuronal damage induced by AAPH.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,9,(2)
MLA：
Guo, An-Chen,et al."Cattle encephalon glycoside and ignotin injection promoted synthesis of glial cell line-derived neurotrophic factor by astrocytes that protected against neuronal damage induced by AAPH".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 9..2(2016):1794-1800
