机构：[a]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China[b]Institute of Neuroscience, Soochow University, Suzhou 215004, China
The role of astrocytes in microglia-induced neuronal death remains controversial. In this study, astrocytes and astrocyte-derived conditioned media (ACM) supported the survival of dopaminergic neurons, and the former was more effective than the latter. In the presence of astrocytes, low concentrations of LPS enhanced the survival of dopaminergic neurons, while high concentrations attenuated survival. LIPS dramatically induced astrocytes to secrete IL-6 in a dose-dependent manner with no effect on secretion of GDNF. Neuron-astrocyte cultures had highest secretion of GDNF, followed by ACM-treated neuron-enriched cultures. After neuron-astrocyte cultures treated with IL-6-neutralizing antibody, both effects of the enhanced and attenuated survival of dopaminergic neurons were abolished Our results indicate that astrocytes play a protective role in the LIPS-induced damage of dopaminergic neurons in certain circumstances, and the interaction between astrocytes and dopaminergic neurons may enhance the protective effect of astrocytes. Suitable activation of astrocytes increases the protective effect while excessive activation attenuates it, and IL-6 might medicate this dual action. The underlying mechanisms related to the secretion of GDNF and proinflammatory factors warrant further investigation. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
基金：
This work was supported by grants from the Program of Sixth
Human Resource Peak of Jiangsu Province (Health 02-2) and the
Technology Plan Project in Suzhou (SS0701)
第一作者机构：[a]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China
通讯作者：
通讯机构：[*1]Department of Neurology, Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, China
推荐引用方式(GB/T 7714)：
Xue-zhong Li,Long-mei Bai,Ya-ping Yang,et al.Effects of IL-6 secreted from astrocytes on the survival of dopaminergic neurons in lipopolysaccharide-induced inflammation[J].NEUROSCIENCE RESEARCH.2009,65(3):252-8.doi:10.1016/j.neures.2009.07.007.
APA：
Xue-zhong Li,Long-mei Bai,Ya-ping Yang,Wei-feng Luo,Wei-dong Hu...&Chun-feng Liu.(2009).Effects of IL-6 secreted from astrocytes on the survival of dopaminergic neurons in lipopolysaccharide-induced inflammation.NEUROSCIENCE RESEARCH,65,(3)
MLA：
Xue-zhong Li,et al."Effects of IL-6 secreted from astrocytes on the survival of dopaminergic neurons in lipopolysaccharide-induced inflammation".NEUROSCIENCE RESEARCH 65..3(2009):252-8
