Surfactant protein A (SP-A), a part of the innate immune system of the lung, performs a vital role in the host defense against Mycobacterium tuberculosis (MTB) infection. In order to investigate the relationship between SFTPA polymorphism variations and Tuberculosis (TB) in a Chinese pediatric group, we conducted a case-control study using single-nucleotide polymorphism (SNP) analysis. Significant difference of the allelic distribution of rs1914663 in SFTPA gene was observed between TB group and control group and, T allele of rs1914663 was associated with increased risk for TB (control vs. TB, OR: 1.42, 95% CI: 1.10-1.81, P = 0.005). In addition, the TC+TT genotype of rs1914663 was higher in PTB and non-severe TB than that in controls. The haplotype comprising rs17881720-A and rs17879335-G was a resistance factor while the haplotype comprising rs1914663-T and rs1059225-G was found to be a susceptibility factor to TB. Using a case-control study, we identified a genetic polymorphism in the SFTPA that regulates host susceptibility to pediatric TB in the Han Chinese population. (C) 2016 Elsevier B.V. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81441067, 81201263]
第一作者机构：[1]Capital Med Univ, Key Lab Major Dis Children, Minist Educ,Natl Key Discipline Pediat, Natl Clin Ctr Project,Minist Sci & Technol People, Beijing, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Beijing Key Lab Pediat Resp Infect Dis, Beijing, Peoples R China;[3]Capital Med Univ, Beijing Pediat Res Inst, Beijing Childrens Hosp, 56 Nanlishi Rd, Beijing 100045, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Key Lab Major Dis Children, Minist Educ,Natl Key Discipline Pediat, Natl Clin Ctr Project,Minist Sci & Technol People, Beijing, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Beijing Key Lab Pediat Resp Infect Dis, Beijing, Peoples R China;[3]Capital Med Univ, Beijing Pediat Res Inst, Beijing Childrens Hosp, 56 Nanlishi Rd, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Li Jieqiong,Qi Hui,Sun Lin,et al.Rs1914663 of SFTPA 1 gene is associated with pediatric tuberculosis in Han Chinese population[J].INFECTION GENETICS AND EVOLUTION.2016,41:16-20.doi:10.1016/j.meegid.2016.03.018.
APA：
Li, Jieqiong,Qi, Hui,Sun, Lin,Shen, Chen,Jiao, Weiwei...&Shen, Adong.(2016).Rs1914663 of SFTPA 1 gene is associated with pediatric tuberculosis in Han Chinese population.INFECTION GENETICS AND EVOLUTION,41,
MLA：
Li, Jieqiong,et al."Rs1914663 of SFTPA 1 gene is associated with pediatric tuberculosis in Han Chinese population".INFECTION GENETICS AND EVOLUTION 41.(2016):16-20
