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Human leukocyte antigen-G overexpression predicts poor clinical outcomes in low-grade gliomas

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机构: [1]Capital Med Univ, Beijing Neurosurg Inst, 6 Tiantanxili, Beijing 100050, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China; [3]Beijing Acad Crit Illness Brain, Dept Clin Oncol, Beijing 100069, Peoples R China
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关键词: Glioma Human leukocyte antigen-G Clinical outcome

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Overexpression of human leukocyte antigen-G (HLA-G), a non-classical major histocompatibility complex class-I molecule associated with immunosuppression, has been reported in various human malignancies. In the present study, we examined the role of HLA-G in gliomas. Clinical characteristics, mRNA expression microarrays and follow-up data pertaining to 293 patients with histologically confirmed gliomas were analyzed. The expression levels of HLA-G were compared between different grades of gliomas and correlated with progression-free survival (PFS) and overall survival (OS) to evaluate its prognostic value. We found that HIA-G was overexpressed in gliomas as compared to that in normal brain tissue samples (-1.288 +/- 0.265). The highest expression levels were in glioblastomas (GBMs), anaplastic gliomas (AGs) and low-grade gliomas (LGGs), in that order (0.328 +/- 0.778, 0.176 +/- 0.881, -0.388 +/- 0.686, respectively). Significant inter-group differences were observed between low-grade and high-grade glioma tissues (p < 0.001 and p < 0.001, t-test, AGs and GBMs, respectively). More astrocytoma patients exhibited increased HLA-G expression as compared to other LGG patients (p = 0.004, Chi-square test). Significant differences were observed with respect to PFS and OS (p = 0.009 and 0.032, log-rank test, for PFS and OS, respectively) between the high- and low-expression subgroups in patients with LGGs. On Cox regression analysis, overexpression of HIA-G appeared to be an independent predictor of clinical outcomes (p = 0.007 and 0.026, for PFS and OS, respectively). Our results suggest that HLA-G expression may serve as a potential biomarker for predicting aggressive tumor grades of gliomas and for histological subtype of LGGs. Elevated HIA-G expression could serve as an independent predictor of poor clinical outcomes in patients with low-grade gliomas. (C) 2016 Elsevier B.V. All rights reserved.

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出版当年[2015]版:
大类 | 3 区 医学
小类 | 4 区 免疫学 4 区 神经科学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 免疫学 4 区 神经科学
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出版当年[2014]版:
Q3 NEUROSCIENCES Q3 IMMUNOLOGY
最新[2023]版:
Q2 NEUROSCIENCES Q3 IMMUNOLOGY

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第一作者机构: [1]Capital Med Univ, Beijing Neurosurg Inst, 6 Tiantanxili, Beijing 100050, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China;
通讯作者:
通讯机构: [1]Capital Med Univ, Beijing Neurosurg Inst, 6 Tiantanxili, Beijing 100050, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China; [3]Beijing Acad Crit Illness Brain, Dept Clin Oncol, Beijing 100069, Peoples R China
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