Multifunctional pDNA-Conjugated Polycationic Au Nanorod-Coated Fe3O4 Hierarchical Nanocomposites for Trimodal Imaging and Combined Photothermal/Gene Therapy
It is very desirable to design multifunctional nanocomposites for theranostic applications via flexible strategies. The synthesis of one new multifunctional polycationic Au nanorod (NR)-coated Fe3O4 nanosphere (NS) hierarchical nanocomposite (Au@pDM/Fe3O4) based on the ternary assemblies of negatively charged Fe3O4 cores (Fe3O4-PDA), polycation-modified Au nanorods (Au NR-pDM), and polycations is proposed. For such nanocomposites, the combined near-infrared absorbance properties of Fe3O4-PDA and Au NR-pDM are applied to photoacoustic imaging and photothermal therapy. Besides, Fe3O4 and Au NR components allow the nanocomposites to serve as MRI and CT contrast agents. The prepared positively charged Au@pDM/Fe3O4 also can complex plasmid DNA into pDNA/Au@pDM/Fe3O4 and efficiently mediated gene therapy. The multifunctional applications of pDNA/Au@pDM/Fe3O4 nanocomposites in trimodal imaging and combined photothermal/gene therapy are demonstrated using a xenografted rat glioma nude mouse model. The present study demonstrates that the proper assembly of different inorganic nanoparticles and polycations is an effective strategy to construct new multifunctional theranostic systems.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [51221002, 51325304, 51473014]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7151002]; Innovation and Promotion Project of Beijing University of Chemical Technology; Collaborative Innovation Center for Cardiovascular Disorders, Beijing Anzhen Hospital Affiliated to the Capital Medical University
通讯机构：[1]Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China;[2]Beijing Univ Chem Technol, Minist Educ, Key Lab Carbon Fiber & Funct Polymers, Beijing 100029, Peoples R China;[3]Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China;[4]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing Neurosurg Inst,Brain Tumor Res Ctr, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Hu Yang,Zhou Yiqiang,Zhao Nana,et al.Multifunctional pDNA-Conjugated Polycationic Au Nanorod-Coated Fe3O4 Hierarchical Nanocomposites for Trimodal Imaging and Combined Photothermal/Gene Therapy[J].SMALL.2016,12(18):2459-2468.doi:10.1002/smll.201600271.
APA：
Hu, Yang,Zhou, Yiqiang,Zhao, Nana,Liu, Fusheng&Xu, Fu-Jian.(2016).Multifunctional pDNA-Conjugated Polycationic Au Nanorod-Coated Fe3O4 Hierarchical Nanocomposites for Trimodal Imaging and Combined Photothermal/Gene Therapy.SMALL,12,(18)
MLA：
Hu, Yang,et al."Multifunctional pDNA-Conjugated Polycationic Au Nanorod-Coated Fe3O4 Hierarchical Nanocomposites for Trimodal Imaging and Combined Photothermal/Gene Therapy".SMALL 12..18(2016):2459-2468
工程技术