机构：[a]Liver Disease Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, P. R. China[b]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, P. R. China[c]Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China[d]Department of Anesthesiology, Beijing Anzhen Hospital Capital Medical University, Beijing, P. R. China临床科室麻醉中心首都医科大学附属安贞医院[e]Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou, P. R. China
Developing multifunctional nanoparticle-based theranostic platform for cancer diagnosis and treatment is highly desirable, however, most of the present theranostic platforms are fabricated via complicated structure/composition design and time-consuming synthesis procedures. Herein, the multifunctional Gd/CeO2-ZrO2/DOX-PEG nanoplatform with single nano-structure was fabricated through a facile route, which possessed MR/CT dual-model imaging and chemotherapy ability. The nanoplatform not only exhibited well-defined shapes, tunable compositions and narrow size distributions, but also presented a well anti-cancer effect and MR/CT imaging ability. Therefore, the Gd/CeO2-ZrO2/DOX-PEG nanoplatform could be applied for chemotherapy as well as dual-model MR/CT imaging.
基金：
Natural Science Foundation of ChinaNational Natural Science Foundation of China [61575044, U1505221, 61520106015]; Science and Technology Infrastructure Construction Program of Fujian Province [2014Y2005]; Natural Science Foundation of Fujian ProvinceNatural Science Foundation of Fujian Province [2014J01389, 2018J01146]; Scientific Foundation of Fuzhou City [2016-S-124-2]
第一作者机构：[a]Liver Disease Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, P. R. China[b]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, P. R. China
通讯作者：
通讯机构：[a]Liver Disease Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, P. R. China[e]Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou, P. R. China[*1]Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou 35007, P. R. China[*2]Liver Disease Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, P. R. China
推荐引用方式(GB/T 7714)：
Wei Zuwu,Wu Ming,Li Zuanfang,et al.Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle[J].DRUG DELIVERY.2018,25(1):353-363.doi:10.1080/10717544.2018.1428241.
APA：
Wei, Zuwu,Wu, Ming,Li, Zuanfang,Lin, Zhan,Zeng, Jinhua...&Zeng, Yongyi.(2018).Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle.DRUG DELIVERY,25,(1)
MLA：
Wei, Zuwu,et al."Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle".DRUG DELIVERY 25..1(2018):353-363
