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Cy5.5 conjugated MnO nanoparticles for magnetic resonance/near-infrared fluorescence dual-modal imaging of brain gliomas

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收录情况： ◇ SCIE ◇ EI

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机构： [1]Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Beijing 100069, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China; [3]Capital Med Univ, Beijing Sanbo Brain Hosp, Dept Neurosurg, Beijing 100093, Peoples R China; [4]Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China

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关键词： Cy5 5 conjugated MnO nanoparticles Dual-modal nanoprobe Magnetic resonance (MR) imaging Near-infrared fluorescence (NIR) imaging Brain gliomas

摘要：

The fusion of molecular and anatomical modalities facilitates more reliable and accurate detection of tumors. Herein, we prepared the PEG-Cy5.5 conjugated MnO nanoparticles (MnO-PEG-Cy5.5 NPs) with magnetic resonance (MR) and near-infrared fluorescence (NIRF) imaging modalities. The applicability of MnO-PEG-Cy5.5 NPs as a dual-modal (MR/NIRF) imaging nanoprobe for the detection of brain gliomas was investigated. In vivo MR contrast enhancement of the MnO-PEG-Cy5.5 nanoprobe in the tumor region was demonstrated. Meanwhile, whole-body NIRF imaging of glioma bearing nude mouse exhibited distinct tumor localization upon injection of MnO-PEG-Cy5.5 NPs. Moreover, ex vivo CLSM imaging of the brain slice hosting glioma indicated the preferential accumulation of MnO-PEG-Cy5.5 NPs in the glioma region. Our results therefore demonstrated the potential of MnO-PEG-Cy5.5 NPs as a dual-modal (MR/NIRF) imaging nanoprobe in improving the diagnostic efficacy by simultaneously providing anatomical information from deep inside the body and more sensitive information at the cellular level. (C) 2015 Elsevier Inc. All rights reserved.

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出版当年[2014]版：

大类 | 3 区化学

小类 | 3 区物理化学

最新[2025]版：

大类 | 1 区

化学

小类 | 2 区物理化学

JCR分区：

出版当年[2013]版：

Q2 CHEMISTRY, PHYSICAL

最新[2023]版：

Q1 CHEMISTRY, PHYSICAL

影响因子： 9.4 最新[2023版] 8.2 最新五年平均 3.552 出版当年[2013版] 3.583 出版当年五年平均 3.172 出版前一年[2012版] 3.368 出版后一年[2014版]

第一作者：

第一作者机构： [2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China;

通讯作者：

通讯机构： [1]Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Beijing 100069, Peoples R China;

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