机构:[1]CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine and i-Lab, CAS Center for Excellence in Brain Science, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China[2]The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, China
A novel multifunctional Ag2S quantum dot (QD)-based nanomedicine of alendronate (Ald)/doxorubicin (DOX)@Ag2S is developed for highly effective bone tumor therapy in an orthotopic model. The bone-targeting and osteolysis inhibition of Ald and the chemotherapeutic effect of DOX on the bone tumor are in situ visualized by Ag2S QDs with emission in the second near-infrared window.
基金:
This work was financially supported by National Natural Science
Foundation of China (Nos. 21671198, 21425103, 81401464, and 21501192), the National Key Research and Development Program
of China (2016YFA0101503), Natural Science Foundation of Jiangsu
Province (BE2016682) and Youth Innovation Promotion Association of
Chinese Academy of Sciences (CAS).
第一作者机构:[1]CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine and i-Lab, CAS Center for Excellence in Brain Science, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China
通讯作者:
推荐引用方式(GB/T 7714):
Li Chunyan,Zhang Yejun,Chen Guangcun,et al.Engineered Multifunctional Nanomedicine for Simultaneous Stereotactic Chemotherapy and Inhibited Osteolysis in an Orthotopic Model of Bone Metastasis[J].ADVANCED MATERIALS.2017,29(13):doi:10.1002/adma.201605754.
APA:
Li, Chunyan,Zhang, Yejun,Chen, Guangcun,Hu, Feng,Zhao, Kui&Wang, Qiangbin.(2017).Engineered Multifunctional Nanomedicine for Simultaneous Stereotactic Chemotherapy and Inhibited Osteolysis in an Orthotopic Model of Bone Metastasis.ADVANCED MATERIALS,29,(13)
MLA:
Li, Chunyan,et al."Engineered Multifunctional Nanomedicine for Simultaneous Stereotactic Chemotherapy and Inhibited Osteolysis in an Orthotopic Model of Bone Metastasis".ADVANCED MATERIALS 29..13(2017)