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Manganese-Doped Carbon Dots for Magnetic Resonance/Optical Dual-Modal Imaging of Tiny Brain Glioma

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收录情况： ◇ SCIE ◇ EI

作者：

机构： [1]School Pharmaceutical Sciences,Capital Medical University, No. 10 Youanmenwaixitoutiao, Beijing 100069, P.R. China [2]School of Basic Medical Sciences, Capital Medical University, No. 10 Youanmenwaixitoutiao, Beijing 100069, P.R. China [3]Department of Stroke Center, People’s Hospital of Puyang, No. 252 Shengli Middle Street, Puyang, Henan 457000, P. R. China [4]Department of Pharmacy, Xuanwu Hospitial of Capital Medical University, No. 45 Changchun Street, Beijing 100053, P.R. China [5]Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, No. 50 Xiangshanyikesong, Beijing 100093, P. R. China

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关键词： carbon dots (CDs) Mn doping dual-modal MR imaging optical imaging tiny brain gliomas

摘要：

Brain gliomas are life-threatening diseases with low survival rates. Early detection and accurate intraoperative location of brain gliomas is vital to improving the prognosis. Herein, we synthesized manganese (Mn)-doped carbon dots (CDs) as magnetic resonance (MR)/optical dual-modal imaging nanoprobes by a one-pot green microwave-assisted route. These ultra-small-sized Mn-doped CDs possess distinct excitation-dependent photoluminescent emissions, high r(1) relaxivity, and low cytotoxicity. The in vivo MR imaging and ex vivo optical imaging of mouse brain with tiny glioma demonstrate that the Mn-doped CDs could lead to an enhanced MR T-1 contrast effect in the tiny brain glioma region, disclosing the great promise of these Mn-doped CDs as MR/optical dual-modal imaging nanoprobes for detection and intraoperative location of tiny brain gliomas.

基金：

基金编号： 7162023 KZ201610025022 81271639 16JL46

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出版当年[2017]版：

大类 | 2 区工程技术

小类 | 3 区材料科学：生物材料

最新[2023]版：

大类 | 2 区医学

小类 | 3 区材料科学：生物材料

JCR分区：

出版当年[2016]版：

Q2 MATERIALS SCIENCE, BIOMATERIALS

最新[2023]版：

Q2 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 5.5 最新[2023版] 5.5 最新五年平均 3.234 出版当年[2016版] 3.234 出版当年五年平均 0 出版前一年[2015版] 4.432 出版后一年[2017版]

第一作者：

第一作者机构： [2]School of Basic Medical Sciences, Capital Medical University, No. 10 Youanmenwaixitoutiao, Beijing 100069, P.R. China

共同第一作者：

通讯作者：

通讯机构： [1]School Pharmaceutical Sciences,Capital Medical University, No. 10 Youanmenwaixitoutiao, Beijing 100069, P.R. China [5]Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, No. 50 Xiangshanyikesong, Beijing 100093, P. R. China

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