Screening for cognitive impairment with the Montreal Cognitive Assessment in Chinese patients with acute mild stroke and transient ischaemic attack: a validation study
Objective: We aimed to establish the cut-off point of the Montreal Cognitive Assessment (MoCA-Beijing) in screening for cognitive impairment (CI) within 2 weeks of mild stroke or transient ischaemic attack (TIA). Methods: A total of 80 acute mild ischaemic stroke patients and 22 TIA patients were recruited. They received the MoCA-Beijing and a formal neuropsychological test battery. CI was defined by 1.5 SD below the established norms on a formal neuropsychological test battery. Results: Most stroke and TIA patients were in their 50s (53.95 +/- 11.43 years old), with greater than primary school level of education. The optimal cut-off point for MoCA-Beijing in discriminating patients with CI from those with no cognitive impairment (NCI) was 22/23 (sensitivity 85%, specificity 88%, positive predictive value=91%, negative predictive value=80%, classification accuracy=86%). The predominant cognitive deficits were characteristic of frontal-subcortical impairment, such as visuomotor speed (46.08%), attention/executive function (42.16%) and visuospatial ability (40.20%). Conclusions: A MoCA-Beijing cut-off score of 22/23 is optimally sensitive and specific for detecting CI after mild stroke, and TIA in the acute stroke phase, and is recommended for routine clinical practice.
基金:
Ministry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology, China [2008ZX09312-008, 200902004, 2011BA108601, 2011BA108602, 2012ZX09303, 2013BA109603]; Beijing Institute for Brain Disorders [BIBD-PXM2013_014226_07_000084]; Beijing Municipal Key Laboratory for Neural Regeneration and Repairing [2015SJZS05]; National Key Basic Research Program of ChinaNational Basic Research Program of China [201106504100]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81571229, 81071015, 30770745]; Natural Science Foundation of Beijing, ChinaBeijing Natural Science Foundation [7082032]; Key Project of Beijing Natural Science FoundationBeijing Natural Science Foundation [kz200910025001]; National Key Technology Research and Development Program of the Ministry of Science and Technology of ChinaNational Key Technology R&D Program [2013BA109603]; project of the Beijing Institute for Brain Disorders [BIBD-PXM2013_014226_07_000084]; High Level Technical Personnel Training Project of Beijing Health System, China [2009-3-26]; Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges Under Beijing Municipality [IDHT20140514]; Capital Clinical Characteristic Application Research [Z121107001012161]; Beijing Healthcare Research Project, China [JING-15-2, JING-15-3]; Excellent Personnel Training Project of Beijing, China [20071D0300400076]; Important National Science and Technology Specific Projects [2011ZX09102-003-01]; Key Project of National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81030062]; Basic-Clinical Research Cooperation Funding of Capital Medical University [10JL49, 14JL15, 2015-JL-PT-X04]; Youth Research Fund, Beijing Tiantan Hospital, Capital Medical University, China [2014-YQN-YS-18, 2015-YQN-15, 2015-YQN-05, 2015-YQN-14, 2015-YQN-17]
第一作者机构:[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China;
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China;[4]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;[5]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Tiantan Clin Trial & Res Ctr Stroke, Beijing, Peoples R China;[6]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Vasc Neurol, Beijing, Peoples R China;
推荐引用方式(GB/T 7714):
Zuo Lijun,Dong Yanhong,Zhu Rongyan,et al.Screening for cognitive impairment with the Montreal Cognitive Assessment in Chinese patients with acute mild stroke and transient ischaemic attack: a validation study[J].BMJ OPEN.2016,6(7):-.doi:10.1136/bmjopen-2016-011310.
APA:
Zuo, Lijun,Dong, Yanhong,Zhu, Rongyan,Jin, Zhao,Li, Zixiao...&Wang, Yongjun.(2016).Screening for cognitive impairment with the Montreal Cognitive Assessment in Chinese patients with acute mild stroke and transient ischaemic attack: a validation study.BMJ OPEN,6,(7)
MLA:
Zuo, Lijun,et al."Screening for cognitive impairment with the Montreal Cognitive Assessment in Chinese patients with acute mild stroke and transient ischaemic attack: a validation study".BMJ OPEN 6..7(2016):-