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Flow-diverter devices in the treatment of intracranial aneurysms: A meta-analysis and systematic review

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机构: [1]Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China; [3]Beijing Neurosurg Inst, Xili 6, Beijing 100050, Peoples R China; [4]Beijing Tiantan Hosp, Xili 6, Beijing 100050, Peoples R China
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关键词: Intracranial aneurysm endovascular treatment flow-diverter stenting

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Objective The purpose of this report was to discuss the overall limitations, safety and efficacy of flow-diverter stenting for intracranial aneurysms. Methods The authors performed a meta-analysis from January 2009 to September 2014 using the terms flow diverter and intracranial aneurysms. Additional studies were identified through references in each reviewed article. Data extraction, performed independently by the authors, included demographic data, technical and clinical complications, morbidity and mortality, aneurismal occlusion rates related to flow-diverter devices. The analysis was performed using a fixed effect. Results Twenty-nine studies with 1524 patients and three to 62 months of follow-up were identified for analysis. The overall technical failure and complication rate was 9.3% (95% CI 6%-12.6%). The rate of procedure-related complication was 14% (95% CI 10.2%-17.9%) and 6.6% (95% CI 4%-9.1%) for morbidity and mortality. Fusiform, dissecting and circumferential aneurysm (OR 3.10, 95% CI 0.93-10.37) were significant risk factors for technical failure and complication. Posterior circulation location (OR 4.03, 95% CI 2.45-6.61), peripheral location (OR 2.74, 95% CI 1.52-4.94) and fusiform, dissecting and circumferential aneurysm (OR 1.95, 95% CI 1.15-3.30) were statistically significant risk factors for procedure-related complications. Posterior circulation location (OR 4.39, 95% CI 2.44-7.90) and peripheral location (OR 3.64, 95% CI 1.74-7.62) were statistically significant risk factors for morbidity and mortality. Conclusions Fusiform, dissecting and circumferential aneurysm, posterior circulation and peripheral locations have greater procedure-related complications.

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第一作者机构: [1]Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China; [3]Beijing Neurosurg Inst, Xili 6, Beijing 100050, Peoples R China; [4]Beijing Tiantan Hosp, Xili 6, Beijing 100050, Peoples R China
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通讯机构: [1]Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Beijing, Peoples R China; [3]Beijing Neurosurg Inst, Xili 6, Beijing 100050, Peoples R China; [4]Beijing Tiantan Hosp, Xili 6, Beijing 100050, Peoples R China
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