资源类型：
收录情况：
◇ 统计源期刊
◇ 北大核心
◇ CSCD-E
文章类型：
机构：
[1]Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China
职能科室
医技科室
药学部
药学部/药剂科
首都医科大学附属天坛医院
出处：
ISSN：
关键词：
HPLC
Human cerebrospinal fluid
Uncertainty
Vancomycin
摘要：
Objective: To evaluate the uncertainty of the determination of vancomycin in human cerebrospinal fluid by HPLC. Methods: The sources of uncertainty of the determination of vancomycin were analyzed and the uncertainty were evaluated and combined. Results: The expanded uncertainty of vancomycin at low (13.2 μg·mL-1) and high (438 μg·mL-1) concentrations were 1.03 and 22.0 μg·mL-1, respectively (P=95%, k=2). Conclusion: The uncertainty of the determination of vancomycin in human cerebrospinal fluid by HPLC is mainly caused by recovery, matrix effect, and sample preparation for low concentrations, and by the matrix effect, sample preparation, and repeatability for high concentrations. Copyright © 2016 by the Editorial Board of Chinese Journal of Contemporary Neurology and Neurosurgery
第一作者：
第一作者机构：
[1]Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China
推荐引用方式(GB/T 7714)：
Wang J.-Q,Zhao Z.-G,Mei S.-H.Uncertainty evaluation of determination of vancomycin in human cerebrospinal fluid by HPLC[J].2016,25(12):
