Objective: To study the association between tumor necrosis factor-α (TNF-α) G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth (SPTB). Methods: The case group enrolled 753 SPTB infants and the control group included 681 term infants. TNF-α G-308A polymorphisms were genotyped using Sequenom MassARRAY®SNP. Results: The frequencies of the allele (G and A) in the case and control groups were not significantly different (P=0.35). The frequencies of the genotypes (GG, GA and AA) in the case and control groups were not significantly different (P=0.64). The logistic regression analysis found that TNF-α G-308A was not associated with genetic susceptibility to SPTB (OR=0.85; 95%CI: 0.61-1.19; P=0.35). Conclusions: There is no association between the polymorphisms of TNF-α G-308A and the genetic susceptibility to SPTB.
语种：
中文
第一作者：
第一作者机构：[1]Bayi Children's Hospital Affiliated to Chinese People's Liberation Army General Hospital, Beijing, 100700, China
推荐引用方式(GB/T 7714)：
Peng W,Yang X,Zhu L.-N,等.Association between tumor necrosis factor-α G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth[J].2016,18(12):
