机构：[1]Capital Med Univ, Beijing Stomatol Hosp, Dept Oral & Maxillofacial Surg, Beijing 100050, Peoples R China;[2]Capital Med Univ, Beijing Tian Tan Hosp, Beijing 100050, Peoples R China;[3]Beijing Chong Wen Stomatol Hosp, Beijing 100062, Peoples R China;[4]Inner Mongolia Med Univ, Affiliated Hosp 3, Inner Mongolia 14010, Peoples R China;[5]Chao Yang Women & Children Hosp, Beijing 10021, Peoples R China;[6]Tsinghua Univ, Dept Mat Sci & Engn, Adv Mat Lab, Beijing 100084, Peoples R China;[7]Capital Med Univ, Beijing Stomatol Hosp, Dept VIP Serv, Beijing 100050, Peoples R China
Aim: To explore the feasibility of repairing minipig mandibular critical-sized defects using mineralized collagen scaffold (MC) combined with in situ periosteal ossification. Materials and Methods: Six minipigs were divided randomly into two groups, with three animals in each group. Segmental bone defect with a length of 6 cm in the right mandible was created and the in situ periosteum was preserved. In Group A, MC was implanted in the defects, while the defects were left empty in Group B. The animals were sacrificed at 12 weeks after surgery. The specimens were evaluated by gross, radiology, histology and bone density examinations. Results: The segmental bone defect was repaired in Group A while it failed in Group B. The bone repair approach in Group A was intramembranous ossification. Conclusions: The critical-sized mandibular defect in minipig can be repaired using MC combined with periosteal ossification, which indicates that MC is an appropriate scaffold for bone tissue engineering.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81372086, 21371106]; National Basic Research Program of ChinaNational Basic Research Program of China [2011CB606205]; Discipline Construction Fund of Beijing Stomatological Hospital [14-09-06]
第一作者机构：[1]Capital Med Univ, Beijing Stomatol Hosp, Dept Oral & Maxillofacial Surg, Beijing 100050, Peoples R China;[2]Capital Med Univ, Beijing Tian Tan Hosp, Beijing 100050, Peoples R China;[3]Beijing Chong Wen Stomatol Hosp, Beijing 100062, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Stomatol Hosp, Dept Oral & Maxillofacial Surg, Beijing 100050, Peoples R China;[7]Capital Med Univ, Beijing Stomatol Hosp, Dept VIP Serv, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Guo Wen-Jin,Han Li-Juan,Xia Rong-Ming,et al.Repair of Mandibular Critical-Sized Defect of Minipig Using In Situ Periosteal Ossification Combined with Mineralized Collagen Scaffolds[J].JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING.2015,5(6):439-444.doi:10.1166/jbt.2015.1274.
APA：
Guo, Wen-Jin,Han, Li-Juan,Xia, Rong-Ming,Cui, Fu-Zhai,Chen, Su...&Pan, Juli.(2015).Repair of Mandibular Critical-Sized Defect of Minipig Using In Situ Periosteal Ossification Combined with Mineralized Collagen Scaffolds.JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING,5,(6)
MLA：
Guo, Wen-Jin,et al."Repair of Mandibular Critical-Sized Defect of Minipig Using In Situ Periosteal Ossification Combined with Mineralized Collagen Scaffolds".JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING 5..6(2015):439-444
