机构：[1]Capital Med Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100069, Peoples R China;[2]Beijing Neurosurg Inst, Beijing 100050, Peoples R China;研究所北京市神经外科研究所首都医科大学附属天坛医院[3]Capital Med Univ, Dept Neurosurg, Beijing Tiantan Hosp, Beijing 100050, Peoples R China;重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[4]Beijing Key Lab Metab Disturbance Related Cardiov, Beijing 100069, Peoples R China;[5]Capital Med Univ, Sch Basic Med Sci, Dept Immunol, 10 Xitoutiao, Beijing 100069, Peoples R China
MicroRNAs are short single-stranded non-coding RNA molecules that function as regulators of tumor progression, including regulation of glioblastoma multiforme, which is a World Health Organization grade IV glioma. Based on the results of a microRNA microarray, which included 198 patients with glioma from the Chinese Glioma Genome Atlas data set, it was observed that microRNA-206 (miR-206) was down-regulated in high-grade (grades III and IV) gliomas compared with grade II gliomas. In addition, high expression of miR-206 was associated with longer overall survival time in glioma patients. The present study aimed to investigate the biological functions of miR-206 in glioma progression in vitro using the LN229 glioma cell line. Cell proliferation was observed to be inhibited subsequent to transfection with miR-206. It was suggested that miR-206 induced cell cycle G(1)/S phase arrest by suppressing the expression of cyclinD2. The results of the present study concluded that miR-206 inhibits glioma progression via the regulation of cyclinD2 and that miR-206 may be a novel biomarker with potential for use as a therapeutic target in gliomas.
基金：
Beijing Municipal Commission of EducationBeijing Municipal Commission of Education [KZ201410025021]; National High Technology Research and Development ProgramNational High Technology Research and Development Program of China [2012AA02A508]; International Science and Technology Cooperation Program [2012DFA30470]; National 973 ProgramNational Basic Research Program of China [2011CB707804]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [91229121, 81201993, 81071626]
第一作者机构：[1]Capital Med Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100069, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100069, Peoples R China;[4]Beijing Key Lab Metab Disturbance Related Cardiov, Beijing 100069, Peoples R China;[5]Capital Med Univ, Sch Basic Med Sci, Dept Immunol, 10 Xitoutiao, Beijing 100069, Peoples R China
推荐引用方式(GB/T 7714)：
Yang Xue,Zhang Chuanbao,Guo Tianzhu,et al.Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas[J].MOLECULAR MEDICINE REPORTS.2015,11(5):3295-3300.doi:10.3892/mmr.2015.3171.
APA：
Yang, Xue,Zhang, Chuanbao,Guo, Tianzhu,Feng, Ying,Liu, Qingyang...&Zhang, Quangeng.(2015).Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas.MOLECULAR MEDICINE REPORTS,11,(5)
MLA：
Yang, Xue,et al."Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas".MOLECULAR MEDICINE REPORTS 11..5(2015):3295-3300
