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MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas

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收录情况： ◇ SCIE

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机构： [1]Nanjing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China; [2]Nanjing Med Univ, State Key Lab Reprod Med, Dept Pathol, Nanjing 210029, Jiangsu, Peoples R China; [3]Nanjing Med Univ, Ctr Canc, Nanjing 210029, Jiangsu, Peoples R China; [4]Cangzhou Cent Hosp, Dept Neurosurg, Cangzhou 061001, Hebei Province, Peoples R China; [5]Southeast Univ, Dept Neurosurg, Xuzhou Cent Hosp, Affiliated Hosp,Med Coll, Xuzhou 221009, Jiangsu, Peoples R China; [6]Capital Med Univ, Dept Neurosurg, Tiantan Hosp, Beijing 100050, Peoples R China; [7]Tianjin Med Univ, Dept Neurosurg, Gen Hosp, Tianjin 300052, Peoples R China

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关键词： glioma miR-181b IGF-1R carcinogenesis

摘要：

MicroRNAs (miRNAs) are single-stranded, 18- to 23-nt RNA molecules that function as regulators of gene expression. Previous studies have shown that microRNAs play important roles in human cancers, including gliomas. Here, we found that expression levels of miR-181b were decreased in gliomas, and we identified IGF-1R as a novel direct target of miR-181b. MiR-181b overexpression inhibited cell proliferation, migration, invasion, and tumorigenesis by targeting IGF-1R and its downstream signaling pathways, PI3K/AKT and MAPK/ERK1/2. Overexpression of IGF-1R rescued the inhibitory effects of miR-181b. In clinical specimens, IGF-1R was overexpressed, and its protein levels were inversely correlated with miR-181b expression. Taken together, our results indicate that miR-181b functions in gliomas to suppress growth by targeting the IGF-1R oncogene and that miR-181b may serve as a novel therapeutic target for gliomas.

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出版当年[2012]版：

大类 | 2 区生物

小类 | 2 区生化与分子生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 4 区生化与分子生物学

JCR分区：

出版当年[2011]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 4.2 最新[2023版] 4.4 最新五年平均 5.095 出版当年[2011版] 5.157 出版当年五年平均 6.051 出版前一年[2010版] 5.088 出版后一年[2012版]

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第一作者机构： [1]Nanjing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China;

通讯作者：

通讯机构： [1]Nanjing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China;

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