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Long non-coding RNAs: The epigenetic regulators involved in the pathogenesis of reproductive disorder

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机构： [a]Peking University Center of Medical Genetics, Beijing, China [b]New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, United States [c]Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, No. 56 Nan-li-shi Road, Beijing, 10045, China

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关键词： Infection Inflammation LncRNAs Reproductive system

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Long non-coding RNAs (lncRNAs) are long single-stranded RNAs without translation potential. LncRNAs function in regulating epigenetic and cellular processes through various mechanisms. Nowadays, rapidly growing evidence has shown that abnormally expressed lncRNAs were involved in various inflammation-related states or diseases. Abnormal inflammation responses contribute to reproductive pathology and play vital roles in developing most disorders of the female reproductive system. In this review, we discussed the history of ncRNAs including lncRNAs, methodologies for lncRNA identification, mechanisms of lncRNA expression and regulation and mainly discussed the expression and function of lncRNAs in the female reproductive system with special focus on the inflammation and infection pathway. By analyzing the present available studies of lncRNA transcripts within the reproductive system and the current understanding of the biology of lncRNAs, we have suggested the important diagnostic and therapeutic roles of lncRNAs in the etiology of reproductive disorders. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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出版当年[2014]版：

大类 | 3 区医学

小类 | 3 区免疫学 3 区生殖生物学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区免疫学 3 区生殖生物学

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