机构:[1]Chinese Univ Hong Kong, Dept Imaging & Intervent Radiol, Shatin, Hong Kong, Peoples R China;[2]Chinese Univ Hong Kong, Res Ctr Med Image Comp, Shatin, Hong Kong, Peoples R China;[3]CUHK Shenzhen Res Inst, Shenzhen, Peoples R China;[4]Chinese Univ Hong Kong, Dept Biomed Engn, Shatin, Hong Kong, Peoples R China;[5]Chinese Univ Hong Kong, Shun Hing Inst Adv Engn, Shatin, Hong Kong, Peoples R China;[6]North Dist Hosp, Dept Psychiat, Sheung Shui, Hong Kong, Peoples R China;[7]Chinese Univ Hong Kong, Dept Psychiat, Shatin, Hong Kong, Peoples R China;[8]Capital Med Univ, Dept Neurol, Beijing Tiantan Hosp, Beijing, Peoples R China;重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[9]Univ Ottawa, Mental Hlth Res Inst, Mind Brain Imaging & Neuroeth, Ottawa, ON KIN 6N5, Canada;[10]Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China;[11]Chinese Univ Hong Kong, Lui Che Woo Inst Innovat Med, Shatin, Hong Kong, Peoples R China
Default-mode network (DMN) has become a prominent network among all large-scale brain networks which can be derived from the resting-state fMRI (rs-fMRI) data. Statistical template labeling the common location of hubs in DMN is favorable in the identification of DMN from tens of components resulted from the independent component analysis (ICA). This paper proposed a novel iterative framework to generate a probabilistic DMN template from a coherent group of 40 healthy subjects. An initial template was visually selected from the independent components derived from group ICA analysis of the concatenated rs-fMRI data of all subjects. An effective similarity measure was designed to choose the best-fit component from all independent components of each subject computed given different component numbers. The selected DMN components for all subjects were averaged to generate an updated DMN template and then used to select the DMN for each subject in the next iteration. This process iterated until the convergence was reached, i.e., the overlapping region between the DMN areas of the current template and the one generated from the previous stage is more than 95%. By validating the constructed DMN template on the rs-fMRI data from another 40 subjects, the generated probabilistic DMN template and the proposed similarity matching mechanism were demonstrated to be effective in automatic selection of independent components from the ICA analysis results.
基金:
Research Grants Council of the Hong Kong Special Administrative Region, ChinaHong Kong Research Grants Council [CUHK 475711, 411910, 411811]; Science, Industry, Trade and Information Commission of Shenzhen Municipality [JC201005250030A, JCYJ20120619152326449]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81201157, 81271653]; Shun Hing Institute of Advanced Engineering, The Chinese University of Hong KongChinese University of Hong Kong [BME-p2-13]
第一作者机构:[1]Chinese Univ Hong Kong, Dept Imaging & Intervent Radiol, Shatin, Hong Kong, Peoples R China;[2]Chinese Univ Hong Kong, Res Ctr Med Image Comp, Shatin, Hong Kong, Peoples R China;[3]CUHK Shenzhen Res Inst, Shenzhen, Peoples R China;[4]Chinese Univ Hong Kong, Dept Biomed Engn, Shatin, Hong Kong, Peoples R China;[5]Chinese Univ Hong Kong, Shun Hing Inst Adv Engn, Shatin, Hong Kong, Peoples R China;
通讯作者:
通讯机构:[10]Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China;[11]Chinese Univ Hong Kong, Lui Che Woo Inst Innovat Med, Shatin, Hong Kong, Peoples R China
推荐引用方式(GB/T 7714):
Wang Defeng,Kong Youyong,Chu Winnie C. W.,et al.Generation of the Probabilistic Template of Default Mode Network Derived from Resting-State fMRI[J].IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING.2014,61(10):2550-2555.doi:10.1109/TBME.2014.2323078.
APA:
Wang, Defeng,Kong, Youyong,Chu, Winnie C. W.,Tam, Cindy W. C.,Lam, Linda C. W....&Shi, Lin.(2014).Generation of the Probabilistic Template of Default Mode Network Derived from Resting-State fMRI.IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,61,(10)
MLA:
Wang, Defeng,et al."Generation of the Probabilistic Template of Default Mode Network Derived from Resting-State fMRI".IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 61..10(2014):2550-2555