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Generation of the Probabilistic Template of Default Mode Network Derived from Resting-State fMRI

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机构: [1]Chinese Univ Hong Kong, Dept Imaging & Intervent Radiol, Shatin, Hong Kong, Peoples R China; [2]Chinese Univ Hong Kong, Res Ctr Med Image Comp, Shatin, Hong Kong, Peoples R China; [3]CUHK Shenzhen Res Inst, Shenzhen, Peoples R China; [4]Chinese Univ Hong Kong, Dept Biomed Engn, Shatin, Hong Kong, Peoples R China; [5]Chinese Univ Hong Kong, Shun Hing Inst Adv Engn, Shatin, Hong Kong, Peoples R China; [6]North Dist Hosp, Dept Psychiat, Sheung Shui, Hong Kong, Peoples R China; [7]Chinese Univ Hong Kong, Dept Psychiat, Shatin, Hong Kong, Peoples R China; [8]Capital Med Univ, Dept Neurol, Beijing Tiantan Hosp, Beijing, Peoples R China; [9]Univ Ottawa, Mental Hlth Res Inst, Mind Brain Imaging & Neuroeth, Ottawa, ON KIN 6N5, Canada; [10]Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China; [11]Chinese Univ Hong Kong, Lui Che Woo Inst Innovat Med, Shatin, Hong Kong, Peoples R China
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关键词: Brain network default mode network (DMN) resting-state fMRI (rs-fMRI) template

摘要:
Default-mode network (DMN) has become a prominent network among all large-scale brain networks which can be derived from the resting-state fMRI (rs-fMRI) data. Statistical template labeling the common location of hubs in DMN is favorable in the identification of DMN from tens of components resulted from the independent component analysis (ICA). This paper proposed a novel iterative framework to generate a probabilistic DMN template from a coherent group of 40 healthy subjects. An initial template was visually selected from the independent components derived from group ICA analysis of the concatenated rs-fMRI data of all subjects. An effective similarity measure was designed to choose the best-fit component from all independent components of each subject computed given different component numbers. The selected DMN components for all subjects were averaged to generate an updated DMN template and then used to select the DMN for each subject in the next iteration. This process iterated until the convergence was reached, i.e., the overlapping region between the DMN areas of the current template and the one generated from the previous stage is more than 95%. By validating the constructed DMN template on the rs-fMRI data from another 40 subjects, the generated probabilistic DMN template and the proposed similarity matching mechanism were demonstrated to be effective in automatic selection of independent components from the ICA analysis results.

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出版当年[2013]版:
大类 | 2 区 工程技术
小类 | 3 区 工程:生物医学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 工程:生物医学
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出版当年[2012]版:
Q2 ENGINEERING, BIOMEDICAL
最新[2023]版:
Q2 ENGINEERING, BIOMEDICAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2012版] 出版当年五年平均 出版前一年[2011版] 出版后一年[2013版]

第一作者:
第一作者机构: [1]Chinese Univ Hong Kong, Dept Imaging & Intervent Radiol, Shatin, Hong Kong, Peoples R China; [2]Chinese Univ Hong Kong, Res Ctr Med Image Comp, Shatin, Hong Kong, Peoples R China; [3]CUHK Shenzhen Res Inst, Shenzhen, Peoples R China; [4]Chinese Univ Hong Kong, Dept Biomed Engn, Shatin, Hong Kong, Peoples R China; [5]Chinese Univ Hong Kong, Shun Hing Inst Adv Engn, Shatin, Hong Kong, Peoples R China;
通讯作者:
通讯机构: [10]Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China; [11]Chinese Univ Hong Kong, Lui Che Woo Inst Innovat Med, Shatin, Hong Kong, Peoples R China
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