Currently, intravenous (IV) thrombolysis within 3 hours from stroke onset is the only approved treatment in acute ischemic stroke (AIS). Although effective, the definition of therapeutic time window and appropriate patient selection still remains controversial. Notably, early endovascular treatment strategies may serve as an adjunct therapy for time window extension in AIS. In this article, we review the safety and efficacy of IV thrombolysis in AIS as it pertains to the optimal time window, the selection of eligible patients, and in combination with endovascular treatment. Combined clinical application of IV thrombolysis and endovascular therapy may improve the therapeutic outcomes for AIS patients.
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China;
通讯作者：
通讯机构：[2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China;[4]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, 6 Tiantan Xili, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Dong,Zou Xinying,Sy Christopher,et al.Thrombolysis and reperfusion: advanced understanding of early management strategies in acute ischemic stroke[J].NEUROLOGICAL RESEARCH.2014,36(5):391-396.doi:10.1179/1743132814Y.0000000349.
APA：
Zhang, Dong,Zou, Xinying,Sy, Christopher,Qin, Haiqiang,Wang, Yilong...&Liu, Liping.(2014).Thrombolysis and reperfusion: advanced understanding of early management strategies in acute ischemic stroke.NEUROLOGICAL RESEARCH,36,(5)
MLA：
Zhang, Dong,et al."Thrombolysis and reperfusion: advanced understanding of early management strategies in acute ischemic stroke".NEUROLOGICAL RESEARCH 36..5(2014):391-396
