To analyze the role of third-generation cephalosporins as prophylactic antibiotics in neurosurgery. We reviewed the literature for data from randomized controlled trials (RCTs) on third-generation cephalosporins compared to other antibiotic regimen in neurosurgery. End point of the RCTs was the occurrence of surgical site infections (SSIs) - data were pooled in a fixed-effects meta-analysis. Five randomized controlled trials enrolling a total of 2209 patients were identified. The pooled odds ratio for SSIs (overall) with third-generation cephalosporins prophylaxis in the five RCTs was 0.94(95% CI, 0.59-1.52; P = 0.81). No significant difference between third-generation cephalosporins and alternative regimen was identified. When analyzing organ SSIs (osteomyelitis, meningitis, and others intracranial infections) in data derived from four RCTs (1596 patients), third-generation cephalosporins failed to show superiority (pooled odds ratio 0.88; 95% CI 0.45-1.74; P = 0.72). Third-generation cephalosporin antibiotic prophylaxis fails to show superiority over conventional regimens regarding both incisional and organ related SSIs in neurosurgery. (C) 2013 Elsevier B.V. All rights reserved.
第一作者机构：[1]Capital Med Univ, Dept Neurosurg, Beijing Tiantan Hosp, Beijing 100050, Peoples R China;[3]Univ Groningen, Univ Med Ctr Groningen, Dept Neurosurg, NL-9713 GZ Groningen, Netherlands;
通讯作者：
通讯机构：[1]Capital Med Univ, Dept Neurosurg, Beijing Tiantan Hosp, Beijing 100050, Peoples R China;[3]Univ Groningen, Univ Med Ctr Groningen, Dept Neurosurg, NL-9713 GZ Groningen, Netherlands;[5]Capital Med Univ, Dept Neurosurg, Beijing Tiantan Hosp, Tiantan Xili 6, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Weiming,Neidert Marian Christoph,Groen Rob J. M.,et al.Third-generation cephalosporins as antibiotic prophylaxis in neurosurgery: What's the evidence?[J].CLINICAL NEUROLOGY AND NEUROSURGERY.2014,116:13-19.doi:10.1016/j.clineuro.2013.10.015.
APA：
Liu, Weiming,Neidert, Marian Christoph,Groen, Rob J. M.,Woernle, Christoph Michael&Grundmann, Hajo.(2014).Third-generation cephalosporins as antibiotic prophylaxis in neurosurgery: What's the evidence?.CLINICAL NEUROLOGY AND NEUROSURGERY,116,
MLA：
Liu, Weiming,et al."Third-generation cephalosporins as antibiotic prophylaxis in neurosurgery: What's the evidence?".CLINICAL NEUROLOGY AND NEUROSURGERY 116.(2014):13-19
