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Surfactant protein B expression in bronchoalveolar lavage fluid of full-term neonates with respiratory distress syndrome

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机构： [1]Affiliated Bayi Children's Hospital, Beijing Military Region General Hospital, No. 5, Nan Mencang, Dongcheng District, Beijing, 100700, China

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关键词： Pulmonary surfactant-associated protein B Pulmonary surfactants Respiratory distress syndrome newborn

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The aim was to investigate the surfactant protein B (SP-B) expression in the bron-choalveolar lavage fluid (BALF) of full-term neonates with respiratory distress syndrome (RDS). The enzyme-linked immunosorbent assay was performed to assess SP-B expression in BALF of 60 full-term neonates with RDS and 23 healthy neonates and correlation of SP-B level with RDS classification according to chest x-ray findings and PaO2/FiO2 before mechanical ventilation in neonates with RDS. The SP-B level was significantly lower in the RDS group (17.63±6.80 ng/mL) than in healthy neonates (103.95±6.38 ng/mL) (P<0.001). The SP-B level correlated positively with PaO2/FiO2 before mechanical ventilation (r=0.838, P<0.001). Moreover, the lower the SP-B level, the more severe was the RDS as determined by chest x-ray (P<0.001). In conclusion, full-term neonates with RDS had reduced SP-B in BALF, which was related to the severity of RDS, suggesting that SP-B supplement may be an effective strategy in the treatment of RDS in full-term neonates.

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出版当年[2013]版：

大类 | 4 区医学

小类 | 4 区医学：内科

最新[2023]版：

大类 | 4 区医学

小类 | 4 区医学：内科

第一作者：

第一作者机构： [1]Affiliated Bayi Children's Hospital, Beijing Military Region General Hospital, No. 5, Nan Mencang, Dongcheng District, Beijing, 100700, China

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