机构：[1]Capital Med Univ, Dept Tradit Chinese Med, Beijing Tiantan Hosp, Beijing 100050, Peoples R China;[2]China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China;[3]Capital Med Univ, Sch Tradit Chinese Med, Dept Prescript, Beng 100069, Peoples R China
Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocorticoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In the present study, Erhuang capsule effectively improved clinical symptoms and neurological function scores, reduced mortality and promoted recovery of neurological functions of mice with experimental autoimmune encephalomyelitis. The mechanism of action involved significant increases in oligodendrocyte precursor cell proliferation in specific regions of the brain and spinal cord, increased oligodendrocyte lineage gene 2 expression and enhanced oligodendrocyte precursor cell differentiation.
基金：
Key Combination Program of Capital Medical Development Foundation [2005-SF-I-001]; Natural Science Foundation of BeijingBeijing Natural Science Foundation [7102051, 7092014]; Beijing Science and Technology Development Foundation of Traditional Chinese Medicine [JJ2009-27]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81072765, 30873230]
Kangning Li,Yongping Fan,Tao Yang,et al.Mechanism of Erhuang capsule for treatment of multiple sclerosis[J].NEURAL REGENERATION RESEARCH.2013,8(6):523-531.doi:10.3969/j.issn.1673-5374.2013.06.005.
APA：
Kangning Li,Yongping Fan,Tao Yang&Lei Wang.(2013).Mechanism of Erhuang capsule for treatment of multiple sclerosis.NEURAL REGENERATION RESEARCH,8,(6)
MLA：
Kangning Li,et al."Mechanism of Erhuang capsule for treatment of multiple sclerosis".NEURAL REGENERATION RESEARCH 8..6(2013):523-531
