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Hospital- and community-associated methicillin-resistant Staphylococcus aureus: a 6-year surveillance study of invasive infections in Chinese children

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机构: [1]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children, Beijing Pediat Res Inst, Beijing 100045, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Natl Key Discipline Pediat, Beijing Pediat Res Inst,Minist Educ, Beijing 100045, Peoples R China; [3]Capital Med Univ, Beijing Childrens Hosp, Dept Bacteriol, Beijing 100045, Peoples R China; [4]Capital Med Univ, Beijing Childrens Hosp, 56 Nan Li Shi Rd, Beijing 100045, Peoples R China
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关键词: Child Genotyping Invasive infection Methicillin-resistant Staphylococcus aureus

摘要:
AimTo investigate and compare the characteristics of invasive hospital-associated (HA) and community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) infections in Chinese children. MethodsClinical data on 59 paediatric patients with invasive MRSA isolated from the normally sterile sites between 2006 and 2011 were obtained from the clinical MRSA surveillance database of Beijing Children's Hospital. The molecular characteristics of the invasive MRSA strains were then analysed. ResultsInvasive MRSA infections rose from 0.89 per 10000 admissions in 2006 to 3.75 in 2011, with a notable increase in invasive CA-MRSA infections from 0 to 2.43 over the same period. The median age of the CA patients (n=29) was 0.33years, compared with 1.17years for the HA patients (n=30). Multisite infection, severe pneumonia and empyema were found in 55.2%, 73.1% and 61.5% of CA children and in 30%, 32% and 24% of HA patients, respectively. ST59-MRSA-IVa accounted for 40.7% of all isolates and the Panton-Valentine leukocidin (PVL) gene carriage rate was significantly higher in patients with necrotizing pneumonia and osteoarthritis than in those with other diseases. ConclusionThe incidence of paediatric invasive MRSA infection, particularly CA-MRSA infection, increased in Chinese children between 2006 and 2011. The invasive infections caused by CA-MRSA occurred more frequently in younger children with more severe pneumonia or empyema.

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出版当年[2012]版:
大类 | 4 区 医学
小类 | 3 区 儿科
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 儿科
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出版当年[2011]版:
Q2 PEDIATRICS
最新[2023]版:
Q1 PEDIATRICS

影响因子: 最新[2023版] 最新五年平均 出版当年[2011版] 出版当年五年平均 出版前一年[2010版] 出版后一年[2012版]

第一作者:
第一作者机构: [1]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children, Beijing Pediat Res Inst, Beijing 100045, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Natl Key Discipline Pediat, Beijing Pediat Res Inst,Minist Educ, Beijing 100045, Peoples R China;
通讯作者:
通讯机构: [1]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children, Beijing Pediat Res Inst, Beijing 100045, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Natl Key Discipline Pediat, Beijing Pediat Res Inst,Minist Educ, Beijing 100045, Peoples R China; [4]Capital Med Univ, Beijing Childrens Hosp, 56 Nan Li Shi Rd, Beijing 100045, Peoples R China
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