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CASP8AP2 is a promising prognostic indicator in pediatric acute lymphoblastic leukemia

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收录情况： ◇ SCIE

作者：

机构： [1]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children, Minist Educ, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Natl Key Discipline Pediat, Minist Educ, Beijing, Peoples R China; [3]Capital Med Univ, Beijing Childrens Hosp, Dept Hematol, Beijing, Peoples R China; [4]Univ Calif San Francisco, Sch Med, Dept Urol, San Francisco, CA 94143 USA; [5]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children, Minist Educ, 56 Nanlishi Rd, Beijing, Peoples R China

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关键词： Pediatric leukemia Acute lymphoblastic leukemia CASP8AP2 Prognostic indicator Bone marrow relapse Minimal residual disease

摘要：

The prognostic significance of caspase 8 associated protein 2 (CASP8AP2) in pediatric ALL is controversial. We determined a cut-off of CASP8AP2 expression in bone marrow samples of 39 newly diagnosed patients, and found a significantly poor bone marrow relapse-free survival (p = 0.019) in low-expression group and verified it in another cohort of 106 patients (p = 0.002). Furthermore, as an independent prognostic factor, CASP8AP2 expression was correlated to minimal residual disease (MRD), and incorporating it with MRD would help to identify patients at greater risk of bone marrow relapse. We also developed an algorithm comprised of clinical risk and CASP8AP2 expression, which could predict bone marrow relapse more accurately. (C) 2011 Elsevier Ltd. All rights reserved.

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中科院(CAS)分区：

出版当年[2011]版：

大类 | 3 区医学

小类 | 4 区血液学 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区血液学 4 区肿瘤学

JCR分区：

出版当年[2010]版：

Q2 ONCOLOGY Q3 HEMATOLOGY

最新[2023]版：

Q3 ONCOLOGY Q3 HEMATOLOGY

影响因子： 2.1 最新[2023版] 2.3 最新五年平均 2.555 出版当年[2010版] 2.309 出版当年五年平均 2.358 出版前一年[2009版] 2.923 出版后一年[2011版]

第一作者：

第一作者机构： [1]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children, Minist Educ, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Natl Key Discipline Pediat, Minist Educ, Beijing, Peoples R China; [3]Capital Med Univ, Beijing Childrens Hosp, Dept Hematol, Beijing, Peoples R China;

通讯作者：

通讯机构： [1]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children, Minist Educ, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Natl Key Discipline Pediat, Minist Educ, Beijing, Peoples R China; [3]Capital Med Univ, Beijing Childrens Hosp, Dept Hematol, Beijing, Peoples R China; [5]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children, Minist Educ, 56 Nanlishi Rd, Beijing, Peoples R China

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CASP8AP2 is a promising prognostic indicator in pediatric acute lymphoblastic leukemia

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