资源类型：
期刊
收录情况：
◇ 统计源期刊
◇ 北大核心
◇ CSCD-C
◇ 中华系列
文章类型：
论著
作者：
Chen, N[1]
*
;
Meng, F.-G[1]
;
Zhang, J.-G[1]
;
Yang, A.-C[1]
;
Liu, H.-G[1]
;
Hu, W.-H[1]
;
Meng, D.-W[1]
;
Zhang, X[1]
;
Liu, C[1]
;
Ge, Y[1]
;
机构：
[1]Beijing Tiantan Hospital, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China
研究所
北京市神经外科研究所
首都医科大学附属天坛医院
出处：
2012,92(47):
ISSN：
0376-2491
关键词：
Amino acids
Anterior nucleus thalamus
Electric stimulation
Epilepsy
摘要：
Objective: To explore the changes of extracellular glutamate (Glu) and γ-aminobutyric acid (GABA) in hippocampus during the high-frequency stimulation of anterior nucleus thalamus (ANT) in epileptic rats. Methods: A total of 30 rats were divided equally into 2 groups: epilepsy model and normal control (n=15 each). Concentric bipolar electrodes were stereotaxically implanted in bilateral ANT. A high-frequency stimulation of 130 Hz was applied in the epilepsy group. Microdialysis probes were unilaterally lowered into hippocampus. The concentrations of Glu and GABA in dialysate samples were determined by high-performance liquid chromatography (HPLC). Results: Electrical stimulation of ANT induced an increase of GABA and a decrease of Glu in hippocampus. Conclusion: An increase of GABA and a decrease of Glu during the electrical stimulation of ANT play an important role in the therapy of epilepsy. Copyright © 2012 by the Chinese Medical Association.
第一作者：
Chen, N
第一作者机构：
[1]Beijing Tiantan Hospital, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Chen N,Meng F.-G,Zhang J.-G,等.Changes of glutamate and γ- aminobutyric acid of extracellular fluid in hippocampus during electrical stimulation of anterior nucleus thalamus in rats[J].2012,92(47):
