Objective: To study Influencing Factors on Creactive protein in neonates. Methods: The neonatal blood samples were collected and simultaneously tested C-reactive protein, blood routine, hepatic function, biochemistry when neonates were admission. There were 220 cases of neonatal that CRP was greater than 8 mg/L in 3196 cases. Mann Whitney U test, Pearson Correlation and multiple linear regression were used for statistical analysis. Results: The preliminary screening results by Mann Whitney U test and Pearson Correlation shows: mean rank: neonatal septicemia (Yes:138.32; No:107.86, U=1381.0, p=0.046), NRDS (Yes:66.44, No:112.16, U=495.5, p=0.046). Pearson Correlation results shows that there are likely to correlation among CRP and HB, HCT, TBIL, DBIL, GLU, r=-0.149, -0.143, -0.164, 0.246, 0.316, respectively, p<0.05. Stepwise regression analysis is further used, dependent variable: CRP, Covariates: neonatal septicemia, NRDS, HB, HCT, TBIL, DBIL, GLU, only DBIL and GLU into regression equation, standardized partial regression coefficient are 0.477,0.311, 95% confidence interval (0.608,2.265), (0.588,9.445); p =0.001, 0.028, respectively. The model has statistical significance (F=9.298, P=0.001), R2=0.341, goodness of fit is relatively low. Conclusion: CRP is positive correlated with DBIL and GLU. Furthermore, DBIL has more positive effect on CRP than GLU.