Human longevity is a complex heritable genetic trait. Based on substantial evidence from model organisms, it is clear that mitochondria play a pivotal role in aging and lifespan. However, the effects that mitochondrial genome variations have upon longevity and longevity-related phenotypes in Chuang people in China have yet to be established. By genotyping 15 variants for 10 haplogroups in 738 Chuang subjects, including 367 long-lived individuals and 371 controls, we found that haplogroup F was significantly associated with longevity in females of Zhuang population of China (p=0.003, OR: 2.01, 95%Cl: 1.263-3.197). Additionally, haplogroup F was related to higher HDL levels (p<0.05) in long-lived individuals. Further analysis suggests that the non-synonymous variant m.13928G>C in haplogroup F was also associated with longevity in female Zhuang Chinese which might account for the beneficial effect of F. (C) 2011 Elsevier Inc. All rights reserved.
基金：
National Scientific Foundation of ChinaNational Natural Science Foundation of China [30972709, 30671110]; National Basic Research Program of China (973 Program)National Basic Research Program of China [2006CB503901]
Feng Jie,Zhang Jianyi,Liu Ming,et al.Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China[J].EXPERIMENTAL GERONTOLOGY.2011,46(12):987-993.doi:10.1016/j.exger.2011.09.001.
APA：
Feng, Jie,Zhang, Jianyi,Liu, Ming,Wan, Gang,Qi, Keyan...&Yang, Ze.(2011).Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China.EXPERIMENTAL GERONTOLOGY,46,(12)
MLA：
Feng, Jie,et al."Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China".EXPERIMENTAL GERONTOLOGY 46..12(2011):987-993
